Evidence map›Paper›PMID 37863912›Full record

ArticleScientific reports2023

White targeted chromatographic screening method of Molnupiravir and its metabolite with degradation kinetics characterization and in-silico toxicity.

Sara I Aboras, Ahmed A Megahed, Fawzy El-Yazbi, Hadir M Maher

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sara I AborasPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, El-Mesallah, Alexandria, 21521, Egypt.
Ahmed A MegahedAl-Basra Health Unit, Alamriya Medical Area, Ministry of Health, Alexandria, Egypt.
Fawzy El-YazbiPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, El-Mesallah, Alexandria, 21521, Egypt.
Hadir M MaherPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, El-Mesallah, Alexandria, 21521, Egypt. hadirrona@yahoo.com.
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 virus triggered a worldwide crisis, with world nations putting up massive efforts to halt its spread. Molnupiravir (MLN) was the first oral, direct-acting antiviral drug approved for nasopharyngeal SARS-CoV-2 infection with favorable safety and tolerability profile. This study aims at determination of MLN and N4-hydroxycytidine (NHC), its main degradation product and its main metabolite, using sensitive, simple, and green HPLC-DAD method. Moreover, under different stress conditions using NaOH, HCl, neutral, H

Indexed as

Antiviral AgentsHepatitis C, ChronicAcidsAlkaliesChromatography, High Pressure LiquidCytidineDrug StabilityHumansHydrogen PeroxideHydroxylaminesAcidsAlkaliesAntiviral AgentsCytidineHydrogen PeroxideHydroxylaminesmolnupiravir

Identifiers

PMID37863912
PMCPMC10589288
OpenAlexW4387814603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.