Evidence map›Paper›PMID 37863888›Full record

ArticleNPJ breast cancer2023

Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers.

Hannah Si Hui Lau, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Yirong Sim, Jelmar Quist, Aye Aye Thike, Puay Hoon Tan, Shazib Pervaiz, Anita Grigoriadis, Kanaga Sabapathy

Abstract read
In one paragraph

Article in NPJ breast cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hannah Si Hui LauDivisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, 168583, Singapore.ORCID http://orcid.org/0000-0001-6757-7216
Veronique Kiak Mien TanSurgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.
Benita Kiat Tee TanSurgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.
Yirong SimSurgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.
Jelmar QuistCancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Aye Aye ThikeDivision of Pathology, Singapore General Hospital, Singapore, 169856, Singapore.
Puay Hoon TanDivision of Pathology, Singapore General Hospital, Singapore, 169856, Singapore.
Shazib PervaizDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Anita GrigoriadisCancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-3434-201X
Kanaga SabapathyDivisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, 168583, Singapore. kanaga.sabapathy@ntu.edu.sg.ORCID http://orcid.org/0000-0002-4346-7386

Funding

Cancer Research UK (CRUK) CRUK/07/012National Cancer Centre of Singapore (National Cancer Centre of Singapore Pte Ltd.) NCCSPG-YR2015-JAN-7National University of Singapore (NUS) NUS Research Scholarship
6 · The paper itself

Abstract

Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive study on the peri-tumoral stroma in the morphologically normal tissues surrounding the tumor is lacking. Here, we examine the heterogeneity in tumors and peri-tumoral stroma from 8 ER

Identifiers

PMID37863888
PMCPMC10589339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.