Evidence map›Paper›PMID 37863261›Full record

ArticleThe Journal of biological chemistry2023

Assembly of SARS-CoV-2 ribonucleosomes by truncated N

Armin N Adly, Maxine Bi, Christopher R Carlson, Abdullah M Syed, Alison Ciling, Jennifer A Doudna, Yifan Cheng, David O Morgan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Mapping SARS-CoV-2 Nucleocapsid Function with Nanobodies.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Evolution of a fuzzy ribonucleoprotein complex in viral assembly.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Armin N AdlyDepartment of Physiology, University of California, San Francisco, California, USA.
Maxine BiDepartment of Biochemistry & Biophysics, University of California, San Francisco, California, USA.
Christopher R CarlsonDepartment of Physiology, University of California, San Francisco, California, USA.
Abdullah M SyedJ. David Gladstone Institutes, San Francisco, California, USA.
Alison CilingJ. David Gladstone Institutes, San Francisco, California, USA.
Jennifer A DoudnaJ. David Gladstone Institutes, San Francisco, California, USA; Department of Molecular and Cell Biology, University of California, Berkeley, California, USA; Howard Hughes Medical Institute, University of California, Berkeley, California, USA; Innovative Genomics Institute, University of California, Berkeley, California, USA; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, California, USA; MBIB Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Yifan ChengDepartment of Biochemistry & Biophysics, University of California, San Francisco, California, USA; Howard Hughes Medical Institute, University of California, San Francisco, California, USA.
David O MorganDepartment of Physiology, University of California, San Francisco, California, USA. Electronic address: David.Morgan@ucsf.edu.
University of California, San Francisco · USGladstone Institutes · USHoward Hughes Medical Institute · USQB3 · US

Funding

Regulatory Enzymes and Systems in Cell Cycle ControlR35GM118053 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAVID Owen MORGAN · 2016 to 2026
$10.3M
Advancing cryo-EM technology to address difficult biological questionsR35GM140847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yifan Cheng · 2021 to 2026
$2.1M
Molecular Biophysics Training GrantT32GM149436 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aashish Manglik · 2023 to 2026
$1.6M
Identifying and inhibiting the SARS-CoV-2 packaging mechanismR21AI159666 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI DOUDNA, JENNIFER A · 2021 to 2021
$520k
NIAID NIH HHS R21 AI159666NIGMS NIH HHS R35 GM118053NIGMS NIH HHS R35 GM140847NIGMS NIH HHS T32 GM149436
6 · The paper itself

Abstract

The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within virions. Assembly of vRNPs is inhibited by phosphorylation of the N protein serine/arginine (SR) region. Several SARS-CoV-2 variants of concern carry N protein mutations that reduce phosphorylation and enhance the efficiency of viral packaging. Variants of the dominant B.1.1 viral lineage also encode a truncated N protein, termed N

Indexed as

Nucleocapsid ProteinsSARS-CoV-2Coronavirus Nucleocapsid ProteinsCOVID-19HumansPhosphoproteinsPhosphorylationRNA, ViralVirus AssemblyCoronavirus Nucleocapsid Proteinsnucleocapsid phosphoprotein, SARS-CoV-2Nucleocapsid ProteinsPhosphoproteinsRNA, ViralN proteinnucleocapsidnucleosomephosphorylationplus-stranded RNA virusRNA binding proteinRNA virusSARS-CoV-2SARS-CoV-2 variant

Identifiers

PMID37863261
PMCPMC10665939
OpenAlexW4387765948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.