Evidence map›Paper›PMID 37863245›Full record

ArticleBiological psychiatry2024

5-HT

John Gregory Bickle, Yifei Li, Amira Millette, Rushell Dixon, Serena Wu, Elena Carazo Arias, Victor Mari Luna, Christoph Anacker

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

John Gregory BickleDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, New York.
Yifei LiDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, New York.
Amira MilletteDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, New York.
Rushell DixonDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, New York.
Serena WuDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, New York.
Elena Carazo AriasDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, New York.
Victor Mari LunaAlzheimer's Center at Temple, Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Christoph AnackerDivision of Systems Neuroscience, Department of Psychiatry, Columbia University and Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, New York; Columbia University Institute for Developmental Sciences, Department of Psychiatry, Columbia University Irving Medical Center, New York, New York; Columbia University Stem Cell Initiative, Columbia University Irving Medical Center, New York, New York. Electronic address: ca2635@cumc.columbia.edu.
Research Foundation For Mental Hygiene · USColumbia University Irving Medical Center · USTemple University · US

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
INVESTIGATING THE ROLE OF HIPPOCAMPUS - ORBITOFRONTAL CIRCUITS FOR COGNITIVE FLEXIBILITYR01MH126105 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Christoph Anacker · 2022 to 2026
$3.6M
IDENTIFYING CELLULAR AND MOLECULAR SUBSTRATES OF TREATMENT-RESISTANT DEPRESSION.R00MH108719 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANACKER, CHRISTOPH · 2019 to 2021
$889k
NIMH NIH HHS P50 MH090964NIMH NIH HHS R00 MH108719NIMH NIH HHS R01 MH126105
6 · The paper itself

Abstract

backgroundHyperactivity of granule cells in the ventral dentate gyrus (vDG) promotes vulnerability to chronic stress. However, which receptors in the vDG could be targeted to inhibit this hyperactivity and confer stress resilience is not known. The serotonin 1A receptor (5-HT

methodsWe exposed male and female mice expressing 5-HT

resultsWe found that activating 5-HT

conclusionsOur findings show that activating 5-HT

Indexed as

Resilience, PsychologicalSerotoninAnimalsCorticosteroneDentate GyrusFemaleMaleMiceReceptor, Serotonin, 5-HT1AStress, PsychologicalCorticosteroneReceptor, Serotonin, 5-HT1ASerotoninHippocampusHPA axisNeurotransmitterSex differencesStress vulnerability

Identifiers

PMID37863245
PMCPMC10978305
OpenAlexW4387747080

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.