Evidence map›Paper›PMID 37863055›Full record

ArticleCell stem cell2023

Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis.

Li Ma, Qing Chang, Fei Pei, Mengmeng Liu, Wei Zhang, Young-Kwon Hong, Yang Chai, Jian-Fu Chen

Open access · hybridAbstract read
In one paragraph

Article in Cell stem cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  15. Ultrasmall inorganic nanoparticles repair damaged meningeal lymphatic vessels to boost Parkinson's disease therapy.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. The glymphatic system in Huntington's disease.Journal of Huntington's disease · 2025
    Review
  17. Article
  18. Review
  19. [Advances in the Study of Calvarial Stem Cells].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Li MaCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Qing ChangCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Fei PeiCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Mengmeng LiuCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Wei ZhangCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
Young-Kwon HongDepartment of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, CA 90033, USA.
Yang ChaiCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: ychai@usc.edu.
Jian-Fu ChenCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: jianfu@usc.edu.
University of Southern California · USUSC Norris Comprehensive Cancer Center · US

Funding

Mechanisms and rescue of craniosynostosis associated with gene-environment interactionR01DE030901 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG, CHEN, JIANFU · 2021 to 2025
$3.0M
Selective neurovascular regulation by a vascular dementia-related noncoding RNA Snord118R21AG070681 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIANFU · 2022 to 2022
$467k
Neurovascular functions of a small RNA Snord118-mediated ribosome biogenesisR21AG075665 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIANFU · 2022 to 2022
$454k
NIA NIH HHS R21 AG070681NIA NIH HHS R21 AG075665NIDCR NIH HHS R01 DE030901
6 · The paper itself

Abstract

The meninges lie in the interface between the skull and brain, harboring lymphatic vasculature and skull progenitor cells (SPCs). How the skull and brain communicate remains largely unknown. We found that impaired meningeal lymphatics and brain perfusion drive neurocognitive defects in Twist1

Indexed as

CraniosynostosesVascular Endothelial Growth Factor CAnimalsEndothelial CellsHumansMeningesMiceSkullStem CellsVascular Endothelial Growth Factor Ccraniosynostosismeningeal lymphaticsmouse behaviorsneurocognitive functionsskull progenitor cells

Identifiers

PMID37863055
PMCPMC10842404
OpenAlexW4387773289

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.