Trial reportThe Journal of clinical endocrinology and metabolism2024
Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults.
Trial report in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01660126 (Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial
Who cites it
15 citing papers in PubMed, 15 citations in OpenAlex.
- Levothyroxine treatment response of cardiometabolic biomarkers in older adults with subclinical hypothyroidism.The Journal of clinical endocrinology and metabolism · 2026Trial
- Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial.Endocrine · 2025Trial
- Levothyroxine Discontinuation: The Potential Role of Excess Iodine Exposure.Endocrinology and metabolism (Seoul, Korea) · 2026Article
- Deciphering the obesity paradox in phenotypic age acceleration through thyroid hormone sensitivity: results from NHANES 2007-2010.Hormones (Athens, Greece) · 2026Article
- Thyroid hormone therapy in a population cohort over two decades indicates persistent overtreatment.European thyroid journal · 2026Article
- Article
- Factors associated with levothyroxine withdrawal and development of a prediction model in primary hypothyroidism.Frontiers in endocrinology · 2026Article
- Thyroid dysfunction in ageing populations.Endocrine connections · 2025Review
- Thyroid disease in ageing populations.Endocrine connections · 2025Article
- Subclinical Hypothyroidism in Moderate-to-Severe Psoriasis: A Cross-Sectional Study of Prevalence and Clinical Implications.Diseases (Basel, Switzerland) · 2025Article
- Is subclinical hypothyroidism associated with cardiovascular disease in the elderly?Endocrine connections · 2025Review
- Women-specific reference ranges for serum TSH in Liguria: the impact of age and year of collection in a single-center cross-sectional study.Thyroid research · 2025Article
- Subclinical hypothyroidism: a new predictor of heart failure with improved ejection fraction in HFrEF patients.Internal and emergency medicine · 2025Article
- Prevalence and Risk Factors of Subclinical Hypothyroidism in Young and Middle-Aged Patients With First-Episode Drug-Naïve Major Depressive Disorder.Depression and anxiety · 2025Article
- Prevalence of abnormal thyroid hormone levels in acute new-onset atrial fibrillation.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 5 countries.
Funding
Abstract
contextWith age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown.
objectiveTo investigate incidence and determinants of spontaneous normalization of TSH levels in older adults with subclinical hypothyroidism.
designPooled data were used from the (1) pretrial population and (2) in-trial placebo group from 2 randomized, double-blind, placebo-controlled trials (Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism Trial and Institute for Evidence-Based Medicine in Old Age thyroid 80-plus thyroid trial).
settingCommunity-dwelling 65+ adults with subclinical hypothyroidism from the Netherlands, Switzerland, Ireland, and the United Kingdom.
participantsThe pretrial population (N = 2335) consisted of older adults with biochemical subclinical hypothyroidism, defined as ≥1 elevated TSH measurement (≥4.60 mIU/L) and a free T4 within the laboratory-specific reference range. Individuals with persistent subclinical hypothyroidism, defined as ≥2 elevated TSH measurements ≥3 months apart, were randomized to levothyroxine/placebo, of which the in-trial placebo group (N = 361) was included.
main outcome measuresIncidence of spontaneous normalization of TSH levels and associations between participant characteristics and normalization.
resultsIn the pretrial phase, TSH levels normalized in 60.8% of participants in a median follow-up of 1 year. In the in-trial phase, levels normalized in 39.9% of participants after 1 year of follow-up. Younger age, female sex, lower initial TSH level, higher initial free T4 level, absence of thyroid peroxidase antibodies, and a follow-up measurement in summer were independent determinants for normalization.
conclusionBecause TSH levels spontaneously normalized in a large proportion of older adults with subclinical hypothyroidism (also after confirmation by repeat measurement), a third measurement may be recommended before considering treatment.
trial registrationClinicalTrials.gov, NCT01660126 and Netherlands Trial Register, NTR3851.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.