Evidence map›Paper›PMID 37862324›Full record

ArticlePloS one2023

Skills to Enhance Positivity in adolescents at risk for suicide: Protocol for a randomized controlled trial.

Shirley Yen, Nazaret Suazo, Jackson Doerr, Natalia Macrynikola, Leanna S Villarreal, Sophia Sodano, Kimberly H M O'Brien, Jennifer C Wolff, Christopher Breault, Brandon E Gibb and 5 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04994873 (Skills to Enhance Positivity in Adolescents at Risk for Suicide), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04994873 narecruitingnot on this map

Skills to Enhance Positivity in Adolescents at Risk for Suicide

TypeinterventionalSponsorBrown UniversityRan2021 to 2026Enrolled216ConditionsSuicide, AttemptedArmsSTEP, Enhanced TAU
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Shirley YenDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
Nazaret SuazoDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States of America.
Jackson DoerrDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
Natalia MacrynikolaDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.ORCID 0000-0003-2988-5503
Leanna S VillarrealNortheastern University, Boston, MA, United States of America.
Sophia SodanoBradley Hospital, Providence, RI, United States of America.
Kimberly H M O'BrienDepartment of Psychiatry, Harvard Medical School, Boston, MA, United States of America.
Jennifer C WolffDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States of America.
Christopher BreaultCenter for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, RI, United States of America.
Brandon E GibbDepartment of Psychology, Binghamton University, Binghamton, NY, United States of America.
Rani ElwyDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States of America.
Christopher W KahlerDepartment of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, United States of America.
Megan RanneyDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States of America.
Richard JonesDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States of America.
Anthony SpiritoDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States of America.
Brown University · USBeth Israel Deaconess Medical Center · USProvidence College · USBinghamton University · USBoston Children's Hospital · USMiriam Hospital · USNortheastern University · US

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI KOGUT, STEPHEN J · 2016 to 2025
$45.0M
Skills to Enhance Positivity (STEP) for Adolescents at Risk for SuicideR01MH123556 · NIMH · BROWN UNIVERSITY · PI SPIRITO, ANTHONY, YEN, SHIRLEY · 2021 to 2025
$2.8M
Skills to Enhance Positivity in Suicidal AdolescentsR34MH101272 · NIMH · BROWN UNIVERSITY · PI YEN, SHIRLEY · 2013 to 2015
$746k
NIGMS NIH HHS U54 GM115677NIMH NIH HHS R01 MH123556NIMH NIH HHS R34 MH101272
6 · The paper itself

Abstract

backgroundSuicide and suicidal behavior during adolescence have been steadily increasing over the past two decades. The preponderance of interventions focuses on crisis intervention, underlying psychiatric disorders, regulating negative affect, and reducing cognitive distortions. However, low positive affectivity may be a mechanism that contributes to adolescent suicidal ideation and behaviors independent of other risk factors. Skills to Enhance Positivity (STEP) is an acceptance-based intervention, designed to increase attention to, and awareness of, positive affect and positive experiences. Results from a pilot RCT demonstrated engagement of the target (positive affect) and a decrease in clinical outcomes (suicidal events; i.e., either a suicide attempt or an emergency intervention for an acute suicidal crisis), providing support to test the clinical effectiveness of STEP in a larger clinical trial with clinical staff implementing the intervention.

objectiveTo test the effectiveness of STEP, compared to Enhanced Treatment as Usual (ETAU), in reducing suicidal events and ideation in adolescents admitted to inpatient psychiatric care due to suicide risk. We hypothesize that those randomized to STEP, compared to ETAU, will have lower rates of suicide events, active suicidal ideation (SI), and depressed mood over the 6-month follow-up period. We hypothesize that those randomized to STEP, compared to ETAU, will demonstrate greater improvement in the hypothesized mechanisms of attention to positive affect stimuli and gratitude and satisfaction with life.

methodsParticipants will be randomized to either STEP or ETAU. STEP consists of four in-person sessions focused on psychoeducation regarding positive and negative affect, mindfulness meditation, gratitude, and savoring. Mood monitoring prompts and skill reminders will be sent via text messaging daily for the first month post-discharge and every other day for the following two months. The ETAU condition will receive text-delivered reminders to use a safety plan provided at discharge from the hospital and healthy habits messages, matched in frequency to the STEP group. This trial was registered on 6 August 2021 (ClinicalTrials.gov NCT04994873).

resultsThe STEP protocol was approved by the National Institute of Mental Health (NIMH) Data and Safety Monitoring Board on March 4, 2022. The RCT is currently in progress. DISCUSSION: The STEP protocol is an innovative, adjunctive treatment that has the potential to have positive effects on adolescent suicidal ideation and attempts beyond that found for standard treatment alone.

Indexed as

AftercareMental DisordersAdolescentHumansPatient DischargeRandomized Controlled Trials as TopicSuicidal IdeationSuicide, Attempted

Identifiers

PMID37862324
PMCPMC10588868
OpenAlexW4387807401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.