SynthesisCurrent environmental health reports2023
Fluoride Exposure and Skeletal Fluorosis: a Systematic Review and Dose-response Meta-analysis.
Synthesis in Current environmental health reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The association of fluoride exposure with bone density and fracture risk: a dose-response meta-analysis.Environmental health : a global access science source · 2025Pooled it
- FI-RADS: an imaging-based scoring system for skeletal fluorosis-adjunctive clinical and biochemical analysis.Quantitative imaging in medicine and surgery · 2026Article
- Impact of sample mass on the reliability of toenail fluoride for exposure assessment.Toxicology and environmental health sciences · 2026Article
- Fluoride exposure and metabolic alterations: a scoping review of metabolomic studies.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Fluoride Levels in Austrian Drinking Water Are Insufficient for Effective Caries Prevention.Dentistry journal · 2025Article
- Assessment of Fluoride Intake Risk via Infusions of Commercial Leaf Teas Available in Poland Using the Target Hazard Quotient Index Approach.Foods (Basel, Switzerland) · 2025Article
- Portable fluoride ion detection using hydrogel test kit integrated metal-organic framework-based ratiometric fluorescence nanoprobe.Mikrochimica acta · 2025Article
- Fluoride Content in Infusions of Selected Teas Available on the Polish Market-An In Vitro Study.Foods (Basel, Switzerland) · 2025Article
- The Association between Fluoride and Bone Mineral Density in US Children and Adolescents: A Pilot Study.Nutrients · 2024Article
- Article
- Ozone Treatment for the Management of Caries in Primary Dentition: A Systematic Review of Clinical Studies.Dentistry journal · 2024Review
- Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China.Frontiers in public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewWe performed a systematic review and meta-analysis on the relation between fluoride exposure and skeletal fluorosis (SF) using a novel statistical methodology for dose-response modeling. RECENT
findingsSkeletal fluorosis, a major health issue that is endemic in some regions, affects millions of people worldwide. However, data regarding the dose-response relation between fluoride exposure and SF are limited and outdated. We included twenty-three studies in the meta-analysis. When comparing the highest versus the lowest fluoride category, the summary risk ratio (RR) for SF prevalence was 2.05 (95% CI 1.60; 2.64), with a value of 2.73 (95% CI 1.92; 3.90) for drinking water and 1.40 (95% CI 0.90; 2.17) for urinary fluoride. The RR by the risk of bias (RoB) was 2.37 (95% CI 1.56; 3.58) and 1.78 (95% CI 1.34; 2.36) for moderate and high RoB studies, respectively. The dose-response curve based on a one-stage cubic spline regression model showed an almost linear positive relation between exposure and SF occurrence starting from relatively low concentrations up to 5 mg/L and 2.5 mg/L, respectively, for water and urinary fluoride, with no substantial increase above this threshold. The RR for developing moderate-severe forms increases at 5.00 mg/L and 2.5 mg/L of water and urinary fluoride, respectively. Better-quality studies are needed to confirm these results, but greater attention should be given to water fluoride levels to prevent SF, in addition to the other potential adverse effects of fluoride exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.