Mechanical behavior and microstructure of porcine brain tissues under pulsed electric fields.

Yiqiang Li, Qixun Zhang, Jiucheng Zhao, Zhaoxin Wang, Xiangyu Zong, Li Yang, Chi Zhang, Hongwei Zhao

Abstract read

In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yiqiang LiSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China.

Qixun ZhangSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China.

Jiucheng ZhaoSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China.

Zhaoxin WangSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China.

Xiangyu ZongSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China.

Li YangSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China.

Chi ZhangSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China. BD0181@jlu.edu.cn.

Hongwei ZhaoSchool of Mechanical & Aerospace Engineering, Jilin University, 5988 Renmin Street, Changchun, 130025, People's Republic of China. hwzhao@jlu.edu.cn.

Jilin University · CNChongqing University · CN

Funding

Foundation for Innovative Research Groups of the National Natural Science Foundation of China 52021003National Science Fund for Distinguished Young Scholars 51925504Natural Science Foundation of Jilin Province 20200201231JCthe Instrument Combining Micro/nano Indentation with Confocal Raman for Synchronous and Cooperative Test 52227810

6 · The paper itself

Abstract

Pulsed electric fields are extensively utilized in clinical treatments, such as subthalamic deep brain stimulation, where electric field loading is in direct contact with brain tissue. However, the alterations in brain tissue's mechanical properties and microstructure due to changes in electric field parameters have not received adequate attention. In this study, the mechanical properties and microstructure of the brain tissue under pulsed electric fields were focused on. Herein, a custom indentation device was equipped with a module for electric field loading. Parameters such as pulse amplitude and frequency were adjusted. The results demonstrated that following an indentation process lasting 5 s and reaching a depth of 1000 μm, and a relaxation process of 175 s, the average shear modulus of brain tissue was reduced, and viscosity decreased. At the same amplitude, high-frequency pulsed electric fields had a smaller effect on brain tissue than low-frequency ones. Furthermore, pulsed electric fields induced cell polarization and reduced the proteoglycan concentration in brain tissue. As pulse frequency increased, cell polarization diminished, and proteoglycan concentration decreased significantly. High-frequency pulsed electric fields applied to brain tissue were found to reduce impedance fluctuation amplitude. This study revealed the effect of pulsed electric fields on the mechanical properties and microstructure of ex vivo brain tissue, providing essential information to promote the advancement of brain tissue electrotherapy in clinical settings.

Indexed as

BrainElectricityAnimalsElectric ImpedanceProteoglycansSwineViscosityProteoglycansBrain tissueDeep brain stimulationIndentationMechanical propertiesMicrostructure

Identifiers

PMID37861916

DOI10.1016/j.jmbbm.2021.104924

OpenAlexW4387798196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.