ArticleEJNMMI physics2023
Ultra-low-dose CT for attenuation correction: dose savings and effect on PET quantification for protocols with and without tin filter.
Article in EJNMMI physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 13 citations in OpenAlex.
- Deep Learning-Based CT-Less Cardiac Segmentation of PET Images: A Robust Methodology for Multi-Tracer Nuclear Cardiovascular Imaging.Journal of imaging informatics in medicine · 2026Article
- Use of diagnostic vs low-dose computed tomography in positron emission tomography-CT examinations.European radiology · 2025Article
- A retrospective comparison of [Physical and engineering sciences in medicine · 2025Article
- Ultra-low dose imaging in a standard axial field-of-view PET.EJNMMI reports · 2025Article
- Deep learning-based segmentation of ultra-low-dose CT images using an optimized nnU-Net model.La Radiologia medica · 2025Article
- CT radiation dose reduction with tin filter for localisation/characterisation level image quality in PET-CT: a phantom study.EJNMMI physics · 2024Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
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Abstract
backgroundUltra-low-dose (ULD) computed tomography (CT) scans should be used when CT is performed only for attenuation correction (AC) of positron emission tomography (PET) data. A tin filter can be used in addition to the standard aluminium bowtie filter to reduce CT radiation dose to patients. The aim was to determine how low CT doses can be, when utilised for PET AC, with and without the tin filter, whilst providing adequate PET quantification.
methodsA water-filled NEMA image quality phantom was imaged in three configurations with
resultsAt each tube voltage, changes in PET quantification were greater with increasing density and reducing mAs. Compared with the reference standard, differences in PET quantification for the standard ULDCT protocol for the three phantoms were ≤ 1.7%, with the water phantom providing a DLP of 7mGy.cm. With tin filter at Sn100kV, differences in PET quantification were negligible (≤ 1.2%) for all phantoms down to 50mAs-ref, proving a DLP of 2.8mGy.cm, at 60% dose reduction compared with standard ULDCT protocol. Below 50mAs-ref, differences in PET quantification were > 2% for at least one phantom (2.3% at 25mAs-ref in SFW; 6.4% at 12mAs-ref in sand). At Sn140kV/7mAs-ref, quantification differences were ≤ 0.6% in water, giving 3.8mGy.cm DLP, but increased to > 2% at bone-equivalent densities.
conclusionsCT protocols for PET AC can provide ultra-low doses with adequate PET quantification. The tin filter can allow 60-87% lower dose than the standard ULDCT protocol for PET AC, depending on tissue density and accepted change in PET quantification.
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