ReviewPediatric nephrology (Berlin, Germany)2024
An update on the role of fluid overload in the prediction of outcome in acute kidney injury.
Review in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 13 citations in OpenAlex.
- Dialytic sodium removal in children with acute kidney injury treated with peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2026Trial
- Outcomes of pediatric urgent-start peritoneal dialysis: a single-center experience from Jordan.Renal failure · 2026Article
- Fluid accumulation and outcomes in children receiving continuous kidney replacement therapy: an appraisal of the WE-ROCK registry.Pediatric nephrology (Berlin, Germany) · 2026Article
- Impact of early volume expansion on severe long-term kidney sequelae in children with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Preventing pediatric acute kidney injury: is it even possible?Pediatric nephrology (Berlin, Germany) · 2026Review
- Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance.Critical care explorations · 2026Observational
- Hypophosphatemia in Pediatric Patients on Continuous Kidney Replacement Therapy-A WE-ROCK Study.Research square · 2026Article
- Research progress on biomarkers for acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance.medRxiv : the preprint server for health sciences · 2025Article
- Role of INM004 Shiga-toxin antibodies in treatment of STEC-HUS.Pediatric nephrology (Berlin, Germany) · 2025Article
- ADVANCE: a biomedical informatics approach to investigate acute kidney injury in infants.Pediatric research · 2025Article
- Characteristics and outcomes of children ≤ 10 kg receiving continuous kidney replacement therapy: a WE-ROCK study.Pediatric nephrology (Berlin, Germany) · 2025Observational
- The association of fluid accumulation and adverse outcomes: the signal is clear. Time to move the field forward.EClinicalMedicine · 2024Article
- Fluid deresuscitation in critically ill children: comparing perspectives of intensivists and nephrologists.Frontiers in pediatrics · 2024Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past two decades, our understanding of the impact of acute kidney injury, disorders of fluid balance, and their interplay have increased significantly. In recent years, the epidemiology and impact of fluid balance, including the pathologic state of fluid overload on outcomes has been studied extensively across multiple pediatric and neonatal populations. A detailed understating of fluid balance has become increasingly important as it is recognized as a target for intervention to continue to work to improve outcomes in these populations. In this review, we provide an update on the epidemiology and outcomes associated with fluid balance disorders and the development of fluid overload in children with acute kidney injury (AKI). This will include a detailed review of consensus definitions of fluid balance, fluid overload, and the methodologies to define them, impact of fluid balance on the diagnosis of AKI and the concept of fluid corrected serum creatinine. This review will also provide detailed descriptions of future directions and the changing paradigms around fluid balance and AKI in critical care nephrology, including the incorporation of the sequential utilization of risk stratification, novel biomarkers, and functional kidney tests (furosemide stress test) into research and ultimately clinical care. Finally, the review will conclude with novel methods currently under study to assess fluid balance and distribution (point of care ultrasound and bioimpedance).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.