Evidence map›Paper›PMID 37861473›Full record

ArticleProtein science : a publication of the Protein Society2023

The origins of nonideality exhibited by monoclonal antibodies and Fab fragments in human serum.

Hayli A Larsen, William M Atkins, Abhinav Nath

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hayli A LarsenDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington, USA.
William M AtkinsDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3173-0175
Abhinav NathDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2895-2973
University of Washington · US

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
NIGMS NIH HHS T32 GM007750
6 · The paper itself

Abstract

The development of therapeutic antibodies remains challenging, time-consuming, and expensive. A key contributing factor is a lack of understanding of how proteins are affected by complex biological environments such as serum and plasma. Nonideality due to attractive or repulsive interactions with cosolutes can alter the stability, aggregation propensity, and binding interactions of proteins in solution. Fluorescence correlation spectroscopy (FCS) can be used to measure apparent second virial coefficient (B

Indexed as

Antibodies, MonoclonalImmunoglobulin Fab FragmentsHumansAntibodies, MonoclonalImmunoglobulin Fab Fragmentsfluorescence correlation spectroscopymacromolecular crowdingnonidealitysecond virial coefficienttherapeutic proteins

Identifiers

PMID37861473
PMCPMC10659951
OpenAlexW4387798982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.