Evidence map›Paper›PMID 37861343›Full record

ArticleJournal of veterinary internal medicine

Differentiation of stable kidney function versus progressive dysfunction in dogs.

Larry D Cowgill, Gilad Segev, Shelly Vaden, Sheri Ross, Cedric Dufayet, Leah A Cohn, Mary Nabity, Giosi Farace, Donald Szlosek, Zenhwa Ouyang and 4 more

Open access · goldAbstract readObservational Study, Veterinary
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Larry D CowgillUniversity of California-Davis, Davis, California, USA.ORCID https://orcid.org/0009-0009-4780-2266
Gilad SegevHebrew University, Jerusalem, Israel.ORCID https://orcid.org/0000-0003-4714-3159
Shelly VadenNorth Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0003-4402-7830
Sheri RossUniversity of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
Cedric DufayetUniversity of California Veterinary Medical Center-San Diego, San Diego, California, USA.
Leah A CohnUniversity of Missouri Veterinary Health Center, Columbia, Missouri, USA.
Mary NabityTexas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0001-6787-822X
Giosi FaraceIDEXX Laboratories, Inc., Westbrook, Maine, USA.ORCID https://orcid.org/0000-0001-7728-1195
Donald SzlosekIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Zenhwa OuyangIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Sarah PetersonIDEXX Laboratories, Inc., Westbrook, Maine, USA.ORCID https://orcid.org/0000-0002-5461-0950
Melissa BeallIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Murthy YerramilliIDEXX Laboratories, Inc., Westbrook, Maine, USA.
David PolzinUniversity of Minnesota, Minneapolis, Minnesota, USA.
IDEXX Laboratories (United States) · USHebrew University of Jerusalem · ILNorth Carolina State University · USTexas A&M University · USUniversity of California, Davis · USUniversity of California San Diego Medical Center · USUniversity of Minnesota · USUniversity of Missouri Health System · USUniversity of Prince Edward Island · CA

Funding

IDEXX Laboratories, Inc.
6 · The paper itself

Abstract

backgroundCirculating creatinine and symmetric dimethylarginine (SDMA) are biomarkers of kidney function that have been used variously to define stable vs progressive chronic kidney disease (CKD). Slope monitoring of inverse biomarker values (creatinine

objectiveAssessment of creatinine ANIMALS: One hundred ten clinically healthy university staff-owned dogs and 29 male colony dogs with progressive X-linked hereditary nephropathy (XLHN).

methodsRetrospective analysis combining 2 prospective observational studies, 1 tracking kidney function biomarkers in healthy dogs (HDs) to a maximum of 3 years, and 1 tracking kidney function biomarkers in male colony dogs with progressive XLHN to a maximum of 1 year. The minimum slope of creatinine

resultsThe stable vs progressive slope cutoff was -0.0119 week × dL/mg for creatinine CONCLUSIONS AND CLINICAL IMPORTANCE: In the studied CKD population, progressive dysfunction can be distinguished from stable kidney function by using the slope of creatinine

Indexed as

Dog DiseasesRenal Insufficiency, ChronicAnimalsBiomarkersCreatinineDogsHumansKidneyMaleRetrospective StudiesBiomarkersCreatininebiomarkercreatininedisease monitoringinverse slopesymmetric dimethylarginine

Identifiers

PMID37861343
PMCPMC10658543
OpenAlexW4387798418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.