Evidence map›Paper›PMID 37861335›Full record

ArticleJournal of virology2023

Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection.

Sanchari Chatterjee, Soumyajit Ghosh, Ankita Datey, Chandan Mahish, Subhasis Chattopadhyay, Soma Chattopadhyay

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sanchari ChatterjeeInstitute of Life Sciences , Bhubaneswar, India.ORCID 0000-0002-4566-5570
Soumyajit GhoshInstitute of Life Sciences , Bhubaneswar, India.ORCID 0000-0003-3991-3010
Ankita DateyInstitute of Life Sciences , Bhubaneswar, India.
Chandan MahishNational Institute of Science Education and Research, an OCC of Homi Bhaba National Institute , Bhubaneswar, Odisha, India.
Subhasis ChattopadhyayNational Institute of Science Education and Research, an OCC of Homi Bhaba National Institute , Bhubaneswar, Odisha, India.
Soma ChattopadhyayInstitute of Life Sciences , Bhubaneswar, India.ORCID 0000-0001-8378-1014
National Institute of Science Education and Research · INRegional Centre for Biotechnology · INInstitute of Life Sciences · IN

Funding

Council of Scientific and Industrial Research, India (CSIR)DBT | Biotechnology Industry Research Assistance Council (BIRAC) BT/NBM0101/02/2018Department of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR20554/Med/29/1107/2016Indian Council of Medical Research (ICMR)
6 · The paper itself

Abstract

importanceBeing obligate parasites, viruses use various host cell machineries in effectively replicating their genome, along with virus-encoded enzymes. In order to carry out infection and pathogenesis, viruses are known to manipulate fundamental cellular processes in cells and interfere with host gene expression. Several viruses interact with the cellular proteins involved in the Wnt/β-catenin pathway; however, reports regarding the involvement of protein components of the Wnt/β-catenin pathway in Chikungunya virus (CHIKV) infection are scarce. Additionally, there are currently no remedies or vaccines available for CHIKV. This is the first study to report that modulation of the Wnt/β-catenin pathway is crucial for effective CHIKV infection. These investigations deepen the understanding of the underlying mechanisms of CHIKV infection and offer new avenue for developing effective countermeasures to efficiently manage CHIKV infection.

Indexed as

Chikungunya FeverChikungunya virusbeta CateninHumansVirus ReplicationWnt Signaling Pathwaybeta CateninChikungunya virusCHIKV-nsP2iCRT14Wnt/β-catenin signaling pathwayβ-catenin

Identifiers

PMID37861335
PMCPMC10688348
OpenAlexW4387798860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.