Trial reportJournal of clinical periodontology2025
Doppler ultrasonographic evaluation of tissue revascularization following connective tissue graft at implant sites.
Trial report in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized controlled trial.Journal of periodontology · 2026Trial
- Tissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures.Journal of periodontal research · 2025Trial
- Characterization of oral biomarkers during early healing at augmented dental implant sites.Journal of periodontal research · 2025Trial
- Doppler ultrasonographic evaluation of tissue revascularization following connective tissue graft at implant sites.Journal of clinical periodontology · 2025Trial
- Comparison of Implant Precision with Robots, Navigation, or Static Guides.Journal of dental research · 2025Trial
- Agreement Between Cone Beam Computed Tomography, Bone Sounding, Pulse-Echo Ultrasound, and Caliper Measurements for Gingival Thickness Assessment: A Method-Comparison Study.Dentistry journal · 2026Article
- New technologies in oral reconstructive medicine: Consensus report of the AAP/OF/SEPA Workshop.Journal of periodontology · 2026Article
- Subepithelial Connective Tissue Grafting Around Dental Implants: From Established Soft-Tissue Benefits to Uncertain Marginal Bone Effects.Journal of clinical medicine · 2026Review
- Flap perfusion of superficial split flap design for guided bone regeneration: A case report with ultrasonography.Clinical advances in periodontics · 2026Article
- Dual-Hybrid Treatment Approach for Peri-Implant Hard and Soft Tissue Stability.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Advancing the diagnosis of peri-implant diseases: From histological foundations to next-generation ultrasonographic diagnostic markers.Journal of periodontology · 2026Review
- Effects of smoking on palatal thickness, density, and vascularization assessed by high-frequency ultrasonography.Scientific reports · 2026Article
- Review
- Periodontal Plastic Surgery: The Past, the Present, the Future.Journal of periodontal research · 2026Article
- Peri-Implant Soft-Tissue Phenotype Modification for Refractory Peri-Implant Mucositis: A 12-Month Prospective Clinical Study With Ultrasonographic Analysis.Journal of periodontal research · 2026Observational
- Soft Tissue Augmentation in Periodontics and Implantology: Current Concepts, Techniques, and Clinical Outcomes.Cureus · 2026Review
- Innovations in microsurgery: The role of non-invasive blood perfusion imaging-A review and framework.Clinical advances in periodontics · 2026Review
- Diagnostic Applications of Ultrasound Imaging in Dental Implantology: A Systematic Review.Journal of clinical medicine · 2025Review
- Three- to 4-year follow-up of the reverse palatal pedicle graft for maxillary palatal recessions.Clinical advances in periodontics · 2025Article
- Organoid-Like Neurovascular Spheroids Promote the Recovery of Hypoxic-Ischemic Skin Flaps Through the Activation of Autophagy.Advanced healthcare materials · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimTo assess the Doppler ultrasonographic tissue perfusion at dental implant sites augmented with connective tissue graft (CTG) using coronally advanced flap (CAF) or tunnel technique (TUN). MATERIALS AND
methodsTwenty-eight patients presenting with isolated healthy peri-implant soft-tissue dehiscence (PSTD) were included in this randomized clinical trial. PSTDs were treated with either CAF + CTG or TUN + CTG. Ultrasound scans were taken at baseline, 1 week, 1 month, 6 months and 12 months. Tissue perfusion at the mid-facial, mesial and distal aspects of the implant sites was assessed by colour Doppler velocity (CDV) and power Doppler imaging (PDI). Early vascularization of the graft and the flap at 1 week and at 1 month were evaluated via dynamic tissue perfusion measurements (DTPMs), including flow intensity (FI), mean perfusion relief intensity (pRI) and mean perfused area (pA).
resultsRegression analysis did not reveal significant differences in terms of mid-facial CDV and PDI changes between CAF and TUN over 12 months (p > .05), while significant differences between the two groups were observed at the interproximal areas (p < .001 for both CDV and PDI changes). Higher early DTPMs were observed at the TUN-treated sites in terms of mean FI of the graft (p = .027) and mean FI (p = .024) and pRI of the flap (p = .031) compared with CAF-treated sites at 1 week. Assessment of the FI direction showed that CTG perfusion at 1 week and at 1 month mainly occurred from the flap towards the implant/bone. Early tissue perfusion outcomes were found to be associated with the 12-month mean PSTD coverage and mucosal thickness gain.
conclusionsDoppler ultrasonography shows tissue perfusion changes occurring at implant sites augmented with CTG. The main differences in tissue perfusion between CAF and TUN were observed at the interproximal sites, with early perfusion associated with clinical and volumetric outcomes at 12 months.
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