ArticlePlant & cell physiology2023
In-Depth Quantification of Cell Division and Elongation Dynamics at the Tip of Growing Arabidopsis Roots Using 4D Microscopy, AI-Assisted Image Processing and Data Sonification.
Article in Plant & cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A multiscale growth atlas of Arabidopsis: linking cell dynamics to organ development.The New phytologist · 2026Pooled it
- EdU-Based Quantitative Analysis of Cell Proliferation in Arabidopsis Root Meristems.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Inferring cell division from cell shape.The Plant cell · 2026Article
- The (un)likelihood of clock-driven lateral root priming; a modeling exploration.The Plant cell · 2026Article
- Hormonal regulation of root growth under moderately elevated temperatures.Annals of botany · 2025Review
- A balance of metabolism and diffusion articulates a gibberellin hormone gradient in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cell lineage tracing: Methods, applications, and challenges.Quantitative biology (Beijing, China) · 2025Review
- Biregionally differentiated growth generates sharp apex and concave joints in leaves.The Plant journal : for cell and molecular biology · 2025Article
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Deep learning image analysis for continuous single-cell imaging of dynamic processes in Plasmodium falciparum-infected erythrocytes.Communications biology · 2025Article
- A long term time lapse microscopy technique for Arabidopsis roots.Frontiers in plant science · 2025Article
- Shaping root architecture: towards understanding the mechanisms involved in lateral root development.Biology direct · 2024Review
- Effect of solution pH on root architecture of four apple rootstocks grown in an aeroponics nutrient misting system.Frontiers in plant science · 2024Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
One of the fundamental questions in plant developmental biology is how cell proliferation and cell expansion coordinately determine organ growth and morphology. An amenable system to address this question is the Arabidopsis root tip, where cell proliferation and elongation occur in spatially separated domains, and cell morphologies can easily be observed using a confocal microscope. While past studies revealed numerous elements of root growth regulation including gene regulatory networks, hormone transport and signaling, cell mechanics and environmental perception, how cells divide and elongate under possible constraints from cell lineages and neighboring cell files has not been analyzed quantitatively. This is mainly due to the technical difficulties in capturing cell division and elongation dynamics at the tip of growing roots, as well as an extremely labor-intensive task of tracing the lineages of frequently dividing cells. Here, we developed a motion-tracking confocal microscope and an Artificial Intelligence (AI)-assisted image-processing pipeline that enables semi-automated quantification of cell division and elongation dynamics at the tip of vertically growing Arabidopsis roots. We also implemented a data sonification tool that facilitates human recognition of cell division synchrony. Using these tools, we revealed previously unnoted lineage-constrained dynamics of cell division and elongation, and their contribution to the root zonation boundaries.
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Registered trials
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