Evidence map›Paper›PMID 37860899›Full record

ArticleDevelopmental psychobiology2023

Pubertal maturation and timing effects on resting state electroencephalography in autistic and comparison youth.

Hannah M Rea, Ann Clawson, Caitlin M Hudac, Megha Santhosh, Raphael A Bernier, Rachel K Earl, Kevin A Pelphrey, Sara Jane Webb, Emily Neuhaus, GENDAAR Consortium

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental psychobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Hannah M ReaDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3786-9725
Ann ClawsonDepartment of Neuropsychology, Children's National Hospital, Washington, DC, USA.
Caitlin M HudacDepartment of Psychology, University of South Carolina, Columbia, South Carolina, USA.
Megha SanthoshCenter on Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.
Raphael A BernierDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Rachel K EarlDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Kevin A PelphreyBrain Institute, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Sara Jane WebbDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Emily NeuhausDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
GENDAAR ConsortiumDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Seattle Children's Hospital · USUniversity of Washington · USChildren's National · USUniversity of South Carolina · USUniversity of Virginia · US

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Phenotypic Characterization of Gene Disrupting Mutations in ASDR01MH100047 · NIMH · UNIVERSITY OF WASHINGTON · PI BERNIER, RAPHAEL A · 2014 to 2018
$2.1M
Healthy Worker Effect, Occupational Exposure to PM and Cardiopulmonary MortalityR01OH010028 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI EISEN, ELLEN AURA · 2012 to 2014
$869k
NICHD NIH HHS P50 HD103524NIH HHS R01 MH100047NIH HHS R01 MH10028NIMH NIH HHS R01 MH100028NIMH NIH HHS R01 MH100047NIOSH CDC HHS R01 OH010028
6 · The paper itself

Abstract

Autistic and comparison individuals differ in resting-state electroencephalography (EEG), such that sex and age explain variability within and between groups. Pubertal maturation and timing may further explain variation, as previous work has suggested alterations in pubertal timing in autistic youth. In a sample from two studies of 181 autistic and 94 comparison youth (8 years to 17 years and 11 months), mixed-effects linear regressions were conducted to assess differences in EEG (midline power for theta, alpha, and beta frequency bands). Alpha power was analyzed as a mediator in the relation between pubertal maturation and timing with autistic traits in the autistic groups to understand the role of puberty in brain-based changes that contribute to functional outcomes. Individuals advanced in puberty exhibited decreased power in all bands. Those who experienced puberty relatively early showed decreased power in theta and beta bands, controlling for age, sex, and diagnosis. Autistic individuals further along in pubertal development exhibited lower social skills. Alpha mediated the relation between puberty and repetitive behaviors. Pubertal maturation and timing appear to play unique roles in the development of cognitive processes for autistic and comparison youth and should be considered in research on developmental variation in resting-state EEG.

Indexed as

Autistic DisorderAdolescentBrainElectroencephalographyHumansPubertySocial Skillsautism spectrum disorderelectroencephalography (EEG)pubertal maturationpubertal timingresting statespectral power

Identifiers

PMID37860899
PMCPMC10713348
OpenAlexW4386094250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.