Evidence map›Paper›PMID 37860692›Full record

ArticleiScience2023

The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination.

Esther J M Taks, Simone J C F M Moorlag, Konstantin Föhse, Elles Simonetti, Christa E van der Gaast-de Jongh, Cornelis H van Werkhoven, Marc J M Bonten, Jaap Ten Oever, Marien I de Jonge, Janneke H H M van de Wijgert and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Esther J M TaksDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Simone J C F M MoorlagDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Konstantin FöhseDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Elles SimonettiRadboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Christa E van der Gaast-de JonghRadboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Cornelis H van WerkhovenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Marc J M BontenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Jaap Ten OeverDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Marien I de JongeRadboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Janneke H H M van de WijgertJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Radboud University Nijmegen · NLUniversity Medical Center Utrecht · NLUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier studies showed that BCG vaccination improves antibody responses of subsequent vaccinations. Similarly, in older volunteers we found an increased IgG receptor-binding domain (RBD) concentration after SARS-CoV-2 infection if they were recently vaccinated with BCG. This study aims to assess the effect of BCG on the serum antibody concentrations induced by COVID-19 vaccination in a population of adults older than 60 years. Serum was collected from 1,555 participants of the BCG-CORONA-ELDERLY trial a year after BCG or placebo, and we analyzed the anti-SARS-CoV-2 antibody concentrations using a fluorescent-microsphere-based multiplex immunoassay. Individuals who received the full primary COVID-19 vaccination series before serum collection and did not test positive for SARS-CoV-2 between inclusion and serum collection were included in analyses (n = 945). We found that BCG vaccination before first COVID-19 vaccine (median 347 days [IQR 329-359]) did not significantly impact the IgG RBD concentration after COVID-19 vaccination in an older European population.

Indexed as

health sciencesmedical sciencemicrobiologyvirology

Identifiers

PMID37860692
PMCPMC10583058
OpenAlexW4387124611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.