Evidence map›Paper›PMID 37860192›Full record

ArticleFrontiers in oncology2023

Association of plasma iron with the risk of incident cancer in Chinese adults with hypertension: a nested case-control study.

Hehao Zhu, Yaping Wei, Qiangqiang He, Yun Song, Lishun Liu, Yong Sun, Hao Zhang, Huiyuan Guo, Xiping Xu, Binyan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Hehao ZhuSchool of Science, China Pharmaceutical University, Nanjing, China.
Yaping WeiCollege of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Qiangqiang HeShenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Yun SongClinical Research Center, Shenzhen Evergreen Medical Institute, Shenzhen, China.
Lishun LiuShenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Yong SunDepartment of Neurosurgery, People's Hospital of Lianyungang City/The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, China.
Hao ZhangCollege of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
Huiyuan GuoCollege of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
Xiping XuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Binyan WangClinical Research Center, Shenzhen Evergreen Medical Institute, Shenzhen, China.
China Agricultural University · CNUniversity Town of Shenzhen · CNChina Pharmaceutical University · CNShanghai University of Medicine and Health Sciences · CNThe First People’s Hospital of Lianyungang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Iron is an essential element for organismal health but excessive iron is potentially toxic. However, few observational studies link plasma iron (PI) concentrations and cancer risk, and the results are inconsistent. Objective: This study aimed to explore the associations of PI concentrations with cancer risk in Chinese adults with hypertension. Methods: We conducted a nested, case-control study, including 223 pairs of incident cancer cases and matched controls from the China Stroke Primary Prevention Trial. The median time between blood sample collection and subsequent cancer event occurrence was 2.13 years. The odds ratio (OR) and 95% confidence interval (CI) for the risk of cancer by PI were estimated from multivariable conditional logistic regression models. Results: There was a nonlinear association between PI concentrations and total cancer risk. When compared with participants in tertile 2 of PI, the ORs of total cancer were 2.17 (95%CI: 1.25-3.85) and 1.29 (95%CI: 0.77-2.19) in participants in PI tertiles 3 and 1, respectively. Furthermore, higher PI was associated with increased digestive system cancer risk (OR=3.25, 95%CI:1.29-8.90), while lower PI was associated with increased risk of non-digestive system cancer (OR=3.32, 95%CI: 1.39-8.71). In a sensitivity analysis, the increases in total cancer risk or digestive system cancer risk were still observed with higher PI after excluding cancer cases occurring within the first year. Conclusion: Our results showed an increased risk of cancer related to higher PI or lower PI in Chinese adults with hypertension. Higher iron levels were linked to an increased risk of digestive system cancers, whereas lower iron levels were linked to an increased risk of non-digestive system cancers.

Indexed as

cancerdigestive cancerhypertensionnested case-control studyplasma iron

Identifiers

PMID37860192
PMCPMC10583576
OpenAlexW4387341711

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.