Evidence map›Paper›PMID 37860084›Full record

ArticleFrontiers in molecular neuroscience2023

Peripheral CCL2 induces inflammatory pain via regulation of

Lamei Li, Yuanying Liu, Wenchao Hu, Jing Yang, Suibin Ma, Zhicheng Tian, Zixuan Cao, Kunqing Pan, Ming Jiang, Xia Liu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. MRGPRX2 as a novel therapeutic target in headache.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lamei LiDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Yuanying LiuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Wenchao HuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Jing YangHeart Hospital, Xi'an International Medical Center Hospital, Xi'an, China.
Suibin MaDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Zhicheng TianDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Zixuan CaoNo.6 Cadet Regiment, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.
Kunqing PanNo.19 Cadet Regiment, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.
Ming JiangSchool of Life Sciences & Research Center for Resource Peptide Drugs, Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, Yan'an University, Yan'an, China.
Xia LiuSchool of Life Sciences & Research Center for Resource Peptide Drugs, Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, Yan'an University, Yan'an, China.
Shengxi WuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Ceng LuoDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Rou-Gang XieDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Air Force Medical University · CNYan'an University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The C-C motif chemokine ligand 2 (CCL2) has been implicated in chronic pain, but its exact mechanism of peripheral sensitization is unknown. In this study, we aimed to clarify the mechanism of CCL2 regulation of ion channels. Our behavioral experiments revealed that ZD7288, a blocker of

Indexed as

dorsal root ganglion (DRG)hyperpolarization-activated current (IH)nociceptorPainthe C-C motif chemokine ligand 2 (CCL2)the C-C motif chemokine receptor 2 (CCR2)

Identifiers

PMID37860084
PMCPMC10582564
OpenAlexW4387341456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.