Evidence map›Paper›PMID 37859769›Full record

ArticleFrontiers in pediatrics2023

Evaluation of IL-6, FoxP3 Treg lymphocytes, intestinal barrier biomarkers and the use of synbiotics in obese adolescents: a pilot study.

Cylmara Aziz, Armando Morales, Walter Pinto, Vanessa Fanchini, Luis Dell Aquila, Carine Sangaleti, Rosilene Elias, Maria Dalboni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cylmara AzizDepartment of Postgraduate Studies in Medicine, Universidade Nove de Julho, São Paulo, Brazil.
Armando MoralesDepartment of Postgraduate Studies in Medicine, Universidade Nove de Julho, São Paulo, Brazil.
Walter PintoDepartment of Postgraduate Studies in Medicine, Universidade Nove de Julho, São Paulo, Brazil.
Vanessa FanchiniDepartment of Postgraduate Studies in Medicine, Universidade Nove de Julho, São Paulo, Brazil.
Luis Dell AquilaDepartment of Postgraduate Studies in Medicine, Universidade Nove de Julho, São Paulo, Brazil.
Carine SangaletiDepartment of Postgraduate Studies in Nanosciences and Biosciences, Universidade Estadual do Centro Oeste, Guarapuava, Brazil.
Rosilene EliasDepartment of Postgraduate Studies in Medicine, Universidade Nove de Julho, São Paulo, Brazil.
Maria DalboniDepartment of Postgraduate Studies in Medicine, Universidade Nove de Julho, São Paulo, Brazil.
Universidade Nove de Julho · BRUniversidade Estadual do Centro-Oeste · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This prospective pilot study evaluated inflammatory and intestinal barrier biomarkers and the effects of a synbiotic in obese adolescents. Methods: Eighteen obese and 20 eutrophic adolescents were evaluated for body composition using bioimpedance analysis (BIA), body mass index (BMI), IL-6 and lipopolysaccharide (LPS) serum levels, CD4 and FoxP3 Treg lymphocytes and monocytes. Synbiotic supplementation for 60 days was also evaluated for these parameters only in obese adolescents. Results: We observed an increase in CD4 lymphocyte (18.0 ± 12.4 vs. 8.9 ± 7.5; Conclusions: Obese adolescents presented a state of microinflammation and intestinal barrier breakdown, and synbiotic supplementation increased the expression of FoxP3 Treg lymphocytes, an anti-inflammatory regulator. Whether the increase in FoxP3 Treg lymphocytes may have an impact on inflammation and outcomes in obese adolescents deserves further evaluation.

Indexed as

adolescentinflammation biomarkerintestinal barrier biomarkerobesitysynbiotic

Identifiers

PMID37859769
PMCPMC10583575
OpenAlexW4387335094

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.