Evidence map›Paper›PMID 37859654›Full record

ArticleFrontiers in neurology2023

Progression risk stratification with six-minute walk gait speed trajectory in multiple sclerosis.

Myla D Goldman, Shanshan Chen, Robert Motl, Rylan Pearsall, Unsong Oh, J Nicholas Brenton

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06672484 (Gait and Cortical Activity Profile of People With Multiple Sclerosis Presenting With Walking Fatigability), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06672484 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Gait and Cortical Activity Profile of People With Multiple Sclerosis Presenting With Walking Fatigability

TypeobservationalSponsorHasselt UniversityRan2024 to 2025Enrolled100ConditionsMultiple Sclerosis, Healthy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Sensors in Multiple Sclerosis.Current neurology and neuroscience reports · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Myla D GoldmanDepartment of Neurology, Virginia Commonwealth University, Richmond, VA, United States.
Shanshan ChenDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA, United States.
Robert MotlDepartment of Kinesiology & Nutrition, University of Illinois at Chicago, Chicago, IL, United States.
Rylan PearsallCollege of Arts and Sciences, University of Virginia, Charlottesville, VA, United States.
Unsong OhDepartment of Neurology, Virginia Commonwealth University, Richmond, VA, United States.
J Nicholas BrentonDepartment of Neurology, Division of Pediatric Neurology, University of Virginia, Charlottesville, VA, United States.
Virginia Commonwealth University · USUniversity of Virginia · USUniversity of Illinois Chicago · US

Funding

Validation of a Motor Fatigue Measure in Multiple SclerosisK23NS062898 · NINDS · UNIVERSITY OF VIRGINIA · PI GOLDMAN, MYLA DENISE · 2009 to 2013
$878k
NINDS NIH HHS K23 NS062898
6 · The paper itself

Abstract

Background: Multiple Sclerosis (MS) disease progression has notable heterogeneity among patients and over time. There is no available single method to predict the risk of progression, which represents a significant and unmet need in MS. Methods: MS and healthy control (HC) participants were recruited for a 2-year observational study. A latent-variable growth mixture model (GMM) was applied to cluster baseline 6-min walk gait speed trajectories (6MW Results: 62 MS and 41 HC participants completed the 2-year study. Within the MS cohort, 90% were relapsing MS. Two distinct patterns of baseline 6 MW Conclusion: Baseline 6 MW

Indexed as

gait speed trajectorygrowth mixture modelmultiple sclerosisprogressionsix-minute walk

Identifiers

PMID37859654
PMCPMC10582752
OpenAlexW4387335490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.