Evidence map›Paper›PMID 37859521›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2023

One right can make a left: sentence processing in the right hemisphere after perinatal stroke.

Kelly C Martin, Anna Seydell-Greenwald, Peter E Turkeltaub, Catherine E Chambers, Margot Giannetti, Alexander W Dromerick, Jessica L Carpenter, Madison M Berl, William D Gaillard, Elissa L Newport

Open access · bronzeAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Right hemisphere language network plasticity in aphasia.Brain : a journal of neurology · 2026
    Article
  3. Identifying left and right hemispheres using functional connectivity.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Right Hemisphere Language Network Plasticity in Aphasia.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kelly C MartinCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
Anna Seydell-GreenwaldCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
Peter E TurkeltaubCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
Catherine E ChambersCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
Margot GiannettiCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
Alexander W DromerickCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
Jessica L CarpenterDivision of Pediatric Neurology, Departments of Pediatrics and Neurology, University of Maryland School of Medicine, Baltimore MD 21201, United States.
Madison M BerlChildren's National Hospital and Center for Neuroscience, Washington, DC 20010, United States.
William D GaillardCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
Elissa L NewportCenter for Brain Plasticity and Recovery, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, United States.
MedStar National Rehabilitation Hospital · USGeorgetown University · USJefferson Hospital for Neuroscience · USUniversity of Maryland, Baltimore · US

Funding

Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI LAUREN KENWORTHY · 2021 to 2026
$9.3M
Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
Training in Neural Injury &PlasticityT32NS041218 · NINDS · GEORGETOWN UNIVERSITY · PI MARK P BURNS, Kathleen Anne Maguire-Zeiss · 2001 to 2026
$3.5M
Language and cognition after perinatal strokeR01DC016902 · NIDCD · GEORGETOWN UNIVERSITY · PI GAILLARD, WILLIAM DAVIS, NEWPORT, ELISSA L · 2019 to 2023
$3.0M
Language development and linguistic processing after left hemisphere perinatal strokeK18DC014558 · NIDCD · GEORGETOWN UNIVERSITY · PI NEWPORT, ELISSA L · 2015 to 2016
$349k
NCATS NIH HHS KL2 TR001432NICHD NIH HHS P50 HD105328NIDCD NIH HHS K18 DC014558NIDCD NIH HHS R01 DC016902NIH HHS R01DC016902NINDS NIH HHS T32 NS041218
6 · The paper itself

Abstract

When brain regions that are critical for a cognitive function in adulthood are irreversibly damaged at birth, what patterns of plasticity support the successful development of that function in an alternative location? Here we investigate the consistency of language organization in the right hemisphere (RH) after a left hemisphere (LH) perinatal stroke. We analyzed fMRI data collected during an auditory sentence comprehension task on 14 people with large cortical LH perinatal arterial ischemic strokes (left hemisphere perinatal stroke (LHPS) participants) and 11 healthy sibling controls using a "top voxel" approach that allowed us to compare the same number of active voxels across each participant and in each hemisphere for controls. We found (1) LHPS participants consistently recruited the same RH areas that were a mirror-image of typical LH areas, and (2) the RH areas recruited in LHPS participants aligned better with the strongly activated LH areas of the typically developed brains of control participants (when flipped images were compared) than the weakly activated RH areas. Our findings suggest that the successful development of language processing in the RH after a LH perinatal stroke may in part depend on recruiting an arrangement of frontotemporal areas reflective of the typical dominant LH.

Indexed as

Language DisordersStrokeBrainComprehensionFunctional LateralityHumansInfant, NewbornLanguageMagnetic Resonance Imagingcognitive developmentfMRIlanguageplasticitystroke

Identifiers

PMID37859521
PMCPMC10690853
OpenAlexW4387798166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.