ReviewClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2023
Peripheral Markers of Suicidal Behavior: Current Findings and Clinical Implications.
Review in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 7 citations in OpenAlex.
- Low 5HTJournal of neurochemistry · 2026Review
- Inflammation and Cognition in Bipolar Disorder: Diverging Paths of Interleukin-6 and Outcomes.International journal of molecular sciences · 2025Article
- Prospective Associations of Serum Tumor Necrosis Factor-Alpha and Employment on Suicidal Behaviors Over 1 Year in Depressive Patients Receiving Psychopharmacotherapy.Psychiatry investigation · 2025Article
- Interplay between Stressful Life Events and Interleukin-1β on 12-week Antidepressant Response in Depressive Patients.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Peripheral biological correlates of suicidality in children and adolescents: A systematic review and meta-analysis.iScience · 2025Article
- Remnant cholesterol and suicide attempts in untreated first-episode major depressive disorder.Frontiers in psychiatry · 2025Article
- Exploring the role of impulsivity, aggression, lipid profiles, and inflammatory markers in suicide attempts: a crossdiagnostic study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Suicide victims and alcohol-related consumption in Brazil: An observational study and a narrative review of the literature.Forensic science, medicine, and pathology · 2024Observational
- Prevalence and related factors of first-time suicide attempts in the past 14 days in Chinese adult patients with first-episode drug-naïve major depressive disorder.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomarkers of suicidal behavior (SB), particularly peripheral biomarkers, may aid in the development of preventive and intervention strategies. The peripheral biomarkers of SB should be easily accessible, cost-effective, and minimally invasive. To identify peripheral biomarkers of SB, we summarized the current knowledge related to SB biomarkers with a focus on suicidal outcomes (suicidal ideation [SI], suicide risk [SR], suicide attempt [SA], and suicide death [SD]), measured site (center or periphery), and study design (cross-sectional or longitudinal). We also evaluated the central findings to validate the findings of peripheral biomarkers of SB. We found reduced peripheral interleukin (IL)-2 levels in individuals with a recent SA, higher cerebrospinal fluid (CSF) IL-6 levels in patients with a current SR and future SD, higher CSF tumor necrosis factor-α levels for current and future SRs, higher high-sensitivity C-reactive protein levels and lower peripheral total cholesterol levels for recent SAs, lower peripheral 5-HT levels for present SR, and a lower folate level for future SR and SA within 1 year. Previous studies have shown inconsistent associations of low peripheral leptin levels with SR and recent SA; therefore, further study is required. Given the multiple determinants of SB and weak associations with single biological markers, combinations of potential biological markers rather than single markers may improve the screening, diagnosis, and prediction of SB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.