Evidence map›Paper›PMID 37858907›Full record

ArticleNeuroImage2023

Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium.

Xi Zhu, Yoojean Kim, Orren Ravid, Xiaofu He, Benjamin Suarez-Jimenez, Sigal Zilcha-Mano, Amit Lazarov, Seonjoo Lee, Chadi G Abdallah, Michael Angstadt and 119 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  11. [A study on post-traumatic stress disorder classification based on multi-atlas multi-kernel graph convolutional network].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

129 authors at 20 institutions in 12 countries.

Xi ZhuDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
Yoojean KimNew York State Psychiatric Institute, New York, NY, USA.
Orren RavidNew York State Psychiatric Institute, New York, NY, USA.
Xiaofu HeDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Benjamin Suarez-JimenezUniversity of Rochester, Rochester, NY, USA.
Sigal Zilcha-ManoUniversity of Haifa, Haifa, Israel.
Amit LazarovTel-Aviv University, Tel Aviv, Israel.
Seonjoo LeeDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
Chadi G AbdallahBaylor College of Medicine, Houston, TX, USA; Yale University School of Medicine, New Haven, CT, USA.
Michael AngstadtUniversity of Michigan, Ann Arbor, MI, USA.
Christopher L AverillBaylor College of Medicine, Houston, TX, USA; Yale University School of Medicine, New Haven, CT, USA.
C Lexi BairdDuke University, Durham, NC, USA.
Lee A BaughSanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Jennifer U BlackfordMunroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Jessica BomyeaUniversity of California San Diego, La Jolla, CA, USA.
Steven E BruceCenter for Trauma Recovery, Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis, MO, USA.
Richard A BryantSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Zhihong CaoDepartment of Radiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
Kyle ChoiUniversity of California San Diego, La Jolla, CA, USA.
Josh CislerDepartment of Psychiatry, University of Texas at Austin, Austin, TX, USA.
Andrew S CottonUniversity of Toledo, Toledo, OH, USA.
Judith K DanielsUniversity of Groningen, Groningen, The Netherlands.
Nicholas D DavenportMinneapolis VA Health Care System, Minneapolis, MN, USA.
Richard J DavidsonUniversity of Wisconsin-Madison, Madison, WI, USA.
Michael D DeBellisDuke University, Durham, NC, USA.
Emily L DennisUniversity of Utah School of Medicine, Salt Lake City, UT, USA.
Maria DensmoreDepartments of Psychology and Psychiatry, Neuroscience Program, Western University, London, ON, Canada; Department of Psychology, University of British Columbia, Okanagan, Kelowna, British Columbia, Canada.
Terri deRoon-CassiniMedical College of Wisconsin, Milwaukee, WI, USA.
Seth G DisnerMinneapolis VA Health Care System, Minneapolis, MN, USA.
Wissam El HageUMR 1253, CIC 1415, University of Tours, CHRU de Tours, INSERM, France.
Amit EtkinStanford University, Stanford, CA, USA.
Negar FaniEmory University Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Kelene A FerchoCivil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, OK, USA.
Jacklynn FitzgeraldMarquette University, Milwaukee, WI, USA.
Gina L ForsterBrain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand.
Jessie L FrijlingDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Elbert GeuzeBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands.
Atilla GonencCognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USA.
Evan M GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Staci GruberCognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USA.
Daniel W GrupeUniversity of Wisconsin-Madison, Madison, WI, USA.
Jeffrey P GuenetteDivision of Neuroradiology, Brigham and Women's Hospital, Boston, MA, USA.
Courtney C HaswellDuke University, Durham, NC, USA.
Ryan J HerringaSchool of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Julia HerzogHeidelberg University, Heidelberg, Germany.
David Bernd HofmannUniversity of Münster, Münster, Germany.
Bobak HosseiniUniversity of Illinois at Chicago, Chicago, IL, USA.
Anna R HudsonGhent University, Ghent, Belgium.
Ashley A HugginsDuke University, Durham, NC, USA.
Jonathan C IpserUniversity of Cape Town, Cape Town, South Africa.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Meilin Jia-RichardsDepartment of Psychology and Neuroscience, Baylor University, Waco, TX, USA.
Tanja JovanovicWayne State University School of Medicine, Detroit, MI, USA.
Milissa L KaufmanDivision of Women's Mental Health, McLean Hospital, Belmont, MA, USA.
Mitzy KennisBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands.
Anthony KingUniversity of Michigan, Ann Arbor, MI, USA.
Philipp KinzelDepartment of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany; Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Saskia B J KochDonders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands.
Inga K KoerteDepartment of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany; Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Sheri M KoopowitzUniversity of Cape Town, Cape Town, South Africa.
Mayuresh S KorgaonkarWestmead Institute for Medical Research, Westmead, NSW, Australia.
John H KrystalYale University School of Medicine, New Haven, CT, USA.
Ruth LaniusDepartment of Neuroscience, Western University, London, ON, Canada.
Christine L LarsonUniversity of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Lauren A M LeboisMcLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA.
Gen LiInstitute of Psychology, Chinese Academy of Sciences, Beijing, China.
Israel LiberzonPsychiatry and Behavioral Science, Texas A&M University Health Science Center, College Station, TX, USA.
Guang Ming LuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Yifeng LuoDepartment of Radiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
Vincent A MagnottaUniversity of Iowa, Iowa City, IA, USA.
Antje MantheyCharité Universitätsmedizin Berlin Campus Charite Mitte: Charite Universitatsmedizin Berlin, Berlin, Germany.
Adi Maron-KatzStanford University, Stanford, CA, USA.
Geoffery MayVISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Katie McLaughlinHarvard University, Boston, MA, USA.
Sven C MuellerGhent University, Ghent, Belgium.
Laura NawijnDepartment of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, VU University, Amsterdam, The Netherlands.
Steven M NelsonDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Richard W J NeufeldDepartments of Psychology and Psychiatry, Neuroscience Program, Western University, London, ON, Canada; Department of Psychology, University of British Columbia, Okanagan, Kelowna, British Columbia, Canada.
Jack B NitschkeUniversity of Wisconsin-Madison, Madison, WI, USA.
Erin M O'LearyUniversity of Toledo, Toledo, OH, USA.
Bunmi O OlatunjiDepartment of Psychology, Vanderbilt University, Nashville, TN, USA.
Miranda OlffDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Matthew PeverillUniversity of Washington, Seattle, WA, USA.
K Luan PhanDepartment of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
Rongfeng QiDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Yann QuidéSchool of Psychology, University of New South Wales, Sydney, NSW, Australia; Neuroscience Research Australia, Randwick, NSW, Australia.
Ivan RektorMasaryk University, Brno, Czechia.
Kerry ResslerMcLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA.
Pavel RihaMasaryk University, Brno, Czechia.
Marisa RossNorthwestern Neighborhood and Networks Initiative, Northwestern University Institute for Policy Research, Evanston, IL, USA.
Isabelle M RossoMcLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA.
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Kelly SambrookUniversity of Washington, Seattle, WA, USA.
Christian SchmahlHeidelberg University, Heidelberg, Germany.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Margaret SheridanUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chiahao ShihUniversity of Toledo, Toledo, OH, USA.
Maurizio SicorelloHeidelberg University, Heidelberg, Germany.
Anika SierkCharité Universitätsmedizin Berlin Campus Charite Mitte: Charite Universitatsmedizin Berlin, Berlin, Germany.
Alan N SimmonsCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Raluca M SimonsUniversity of South Dakota, Vermillion, SD, USA.
Jeffrey S SimonsUniversity of South Dakota, Vermillion, SD, USA.
Scott R SponheimMinneapolis VA Health Care System, Minneapolis, MN, USA; University of Minnesota, Minneapolis, MN, USA.
Murray B SteinUniversity of California San Diego, La Jolla, CA, USA.
Dan J SteinUniversity of Cape Town, Cape Town, South Africa.
Jennifer S StevensEmory University Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Thomas StraubeUniversity of Münster, Münster, Germany.
Delin SunDuke University, Durham, NC, USA.
Jean ThébergeDepartments of Psychology and Psychiatry, Neuroscience Program, Western University, London, ON, Canada; Department of Psychology, University of British Columbia, Okanagan, Kelowna, British Columbia, Canada.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Nic J A van der WeeLeiden University Medical Center, Leiden, The Netherlands.
Steven J A van der WerffLeiden University Medical Center, Leiden, The Netherlands.
Theo G M van ErpUniversity of California, Irvine, Irvine, CA, USA.
Sanne J H van RooijEmory University Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Mirjam van ZuidenDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Tim VarkevisserBrain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands.
Dick J VeltmanDepartment of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, VU University, Amsterdam, The Netherlands.
Robert R J M VermeirenLeiden University Medical Center, Leiden, The Netherlands.
Henrik WalterCharité Universitätsmedizin Berlin Campus Charite Mitte: Charite Universitatsmedizin Berlin, Berlin, Germany.
Li WangInstitute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Xin WangUniversity of Toledo, Toledo, OH, USA.
Carissa WeisMedical College of Wisconsin, Milwaukee, WI, USA.
Sherry WinternitzDivision of Women's Mental Health, McLean Hospital, Belmont, MA, USA.
Hong XieUniversity of Toledo, Toledo, OH, USA.
Ye ZhuInstitute of Psychology, Chinese Academy of Sciences, Beijing, China.
Melanie WallDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
Yuval NeriaDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Rajendra A MoreyDuke University, Durham, NC, USA.
McLean Hospital · USUNSW Sydney · AUUniversity of Southern California · USDuke University · USUniversity of Cape Town · ZAColumbia University Irving Medical Center · USHarvard University · USJiangsu University · CNUniversity of Wisconsin–Madison · USWestern University · CABaylor College of Medicine · USBrigham and Women's Hospital · USEmory University · USHeidelberg University · DELeiden University Medical Center · NLUniversity of South Dakota · USAmsterdam UMC Location University of Amsterdam · NLGhent University Hospital · BELudwig-Maximilians-Universität München · DEMarquette University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MAILICK, MARSHA RUTH · 1985 to 2015
$25.2M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Neural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6M
NEUROSCIENCE TRAINING PROGRAMT32GM007507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 1985 to 2017
$9.3M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized PeopleR01AT011267 · NCCIH · EMORY UNIVERSITY · PI FANI, NEGAR, SIEGLE, GREG J · 2021 to 2025
$4.1M
Multimodal Approaches to Neurobiology of Traumatic DissociationR01MH119227 · NIMH · MCLEAN HOSPITAL · PI KAUFMAN, MILISSA L · 2020 to 2024
$3.7M
Computational Biases of Learning and Decision-Making in PTSDR01MH119132 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI CISLER, JOSHUA M · 2019 to 2023
$2.6M
Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD SymptomsR01MH129832 · NIMH · DUKE UNIVERSITY · PI MOREY, RAJENDRA A, SCHMAAL, LIANNE · 2022 to 2025
$2.3M
CSRD VA IK2 CX001600NCATS NIH HHS UL1 TR001863NCCIH NIH HHS R01 AT011267NIBIB NIH HHS U54 EB020403NICHD NIH HHS P30 HD003352NICHD NIH HHS P50 HD103556NIGMS NIH HHS T32 GM007507NIMH NIH HHS F31 MH122047NIMH NIH HHS K01 MH118467NIMH NIH HHS K01 MH122774NIMH NIH HHS K23 MH090366NIMH NIH HHS R01 MH043454NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH119132NIMH NIH HHS R01 MH119227NIMH NIH HHS R01 MH129832NIMH NIH HHS R21 MH097784NIMH NIH HHS R21 MH125277NIMH NIH HHS R33 MH108753NIMH NIH HHS R61 MH127005NIMH NIH HHS T32 MH018931NINDS NIH HHS R61 NS120249RRD VA IK2 RX002922
6 · The paper itself

Abstract

backgroundRecent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, and different imaging collection protocols, limit the ability to directly compare and generalize their results. Here we aimed to classify individuals with PTSD versus controls and assess the generalizability using a large heterogeneous brain datasets from the ENIGMA-PGC PTSD Working group.

methodsWe analyzed brain MRI data from 3,477 structural-MRI; 2,495 resting state-fMRI; and 1,952 diffusion-MRI. First, we identified the brain features that best distinguish individuals with PTSD from controls using traditional machine learning methods. Second, we assessed the utility of the denoising variational autoencoder (DVAE) and evaluated its classification performance. Third, we assessed the generalizability and reproducibility of both models using leave-one-site-out cross-validation procedure for each modality.

resultsWe found lower performance in classifying PTSD vs. controls with data from over 20 sites (60 % test AUC for s-MRI, 59 % for rs-fMRI and 56 % for d-MRI), as compared to other studies run on single-site data. The performance increased when classifying PTSD from HC without trauma history in each modality (75 % AUC). The classification performance remained intact when applying the DVAE framework, which reduced the number of features. Finally, we found that the DVAE framework achieved better generalization to unseen datasets compared with the traditional machine learning frameworks, albeit performance was slightly above chance.

conclusionThese results have the potential to provide a baseline classification performance for PTSD when using large scale neuroimaging datasets. Our findings show that the control group used can heavily affect classification performance. The DVAE framework provided better generalizability for the multi-site data. This may be more significant in clinical practice since the neuroimaging-based diagnostic DVAE classification models are much less site-specific, rendering them more generalizable.

Indexed as

Stress Disorders, Post-TraumaticBig DataBrainHumansMagnetic Resonance ImagingNeuroimagingReproducibility of ResultsClassificationDeep learningMachine learningMultimodal MRIPosttraumatic stress disorder

Identifiers

PMID37858907
PMCPMC10842116
OpenAlexW4387745684

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.