Evidence map›Paper›PMID 37858734›Full record

ArticleJournal of affective disorders2024

Polygenic risk for depression and anterior and posterior hippocampal volume in children and adolescents.

Hailee Hurtado, Melissa Hansen, Jordan Strack, Uku Vainik, Alexandra L Decker, Budhachandra Khundrakpam, Katherine Duncan, Amy S Finn, Donald J Mabbott, Emily C Merz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Hailee HurtadoDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Melissa HansenDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Jordan StrackDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Uku VainikUniversity of Tartu, Tartu, Estonia; Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Alexandra L DeckerDepartment of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Budhachandra KhundrakpamMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Katherine DuncanDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Amy S FinnDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Donald J MabbottDepartment of Psychology, University of Toronto, Toronto, ON, Canada.; Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.; Department of Psychology, Hospital for Sick Children, Toronto, ON, Canada.
Emily C MerzDepartment of Psychology, Colorado State University, Fort Collins, CO, USA. Electronic address: emily.merz@colostate.edu.
Colorado State University · USUniversity of Toronto · CAMontreal Neurological Institute and Hospital · CAMcGovern Institute for Brain Research · US

Funding

Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
NIDA NIH HHS RC2 DA029475
6 · The paper itself

Abstract

backgroundDepression has frequently been associated with smaller hippocampal volume. The hippocampus varies in function along its anterior-posterior axis, with the anterior hippocampus more strongly associated with stress and emotion processing. The goals of this study were to examine the associations among parental history of anxiety/depression, polygenic risk scores for depression (PGS-DEP), and anterior and posterior hippocampal volumes in children and adolescents. To examine specificity to PGS-DEP, we examined associations of educational attainment polygenic scores (PGS-EA) with anterior and posterior hippocampal volume.

methodsParticipants were 350 3- to 21-year-olds (46 % female). PGS-DEP and PGS-EA were computed based on recent, large-scale genome-wide association studies. High-resolution, T1-weighted magnetic resonance imaging (MRI) data were acquired, and a semi-automated approach was used to segment the hippocampus into anterior and posterior subregions.

resultsChildren and adolescents with higher polygenic risk for depression were more likely to have a parent with a history of anxiety/depression. Higher polygenic risk for depression was significantly associated with smaller anterior but not posterior hippocampal volume. PGS-EA was not associated with anterior or posterior hippocampal volumes. LIMITATIONS: Participants in these analyses were all of European ancestry.

conclusionsPolygenic risk for depression may lead to smaller anterior but not posterior hippocampal volume in children and adolescents, and there may be specificity of these effects to PGS-DEP rather than PGS-EA. These findings may inform the earlier identification of those in need of support and the design of more effective, personalized treatment strategies. DECLARATIONS OF INTEREST: none. DECLARATIONS OF INTEREST: None.

Indexed as

DepressionGenome-Wide Association StudyAdolescentChildEducational StatusFemaleHippocampusHumansMagnetic Resonance ImagingMaleBrain structureDepressionGeneticshippocampus

Identifiers

PMID37858734
PMCPMC10842073
OpenAlexW4387745559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.