Evidence map›Paper›PMID 37858527›Full record

ArticleMethods in enzymology2023

Analysis of continuous enzyme kinetic data using ICEKAT.

Karina L Bursch, Michael D Olp, Brian C Smith

Abstract read
In one paragraph

Article in Methods in enzymology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karina L BurschDepartment of Biochemistry, Medical College of Wisconsin, Watertown Plank Road, Milwaukee, WI, United States.
Michael D OlpDepartment of Pathology, University of Michigan, Ann Arbor, MI, United States.
Brian C SmithDepartment of Biochemistry, Medical College of Wisconsin, Watertown Plank Road, Milwaukee, WI, United States; Program in Chemical Biology, Medical College of Wisconsin, Watertown Plank Road, Milwaukee, WI, United States. Electronic address: brismith@mcw.edu.

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Discovering and Exploiting Selectivity within Tandem BromodomainsR35GM128840 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI Brian Christopher Smith · 2018 to 2026
$2.7M
PBRM1 bromodomain missense mutations in ccRCC vascular signalingF30CA278386 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Karina Lynn Bursch · 2023 to 2026
$205k
NCI NIH HHS F30 CA278386NIGMS NIH HHS R35 GM128840NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

ICEKAT (Interactive Continuous Enzyme Analysis Tool) is an interactive web-based program for calculating initial rates and kinetic parameters (e.g., V

Indexed as

Enzyme AssaysSoftwareKineticsReproducibility of ResultsComputer modelingEC(50)Enzyme activatorEnzyme catalysisEnzyme inhibitorEnzyme kineticsIC(50)Initial rateMichaelis–MentenSteady-state kinetics

Identifiers

PMID37858527
PMCPMC10691744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.