Evidence map›Paper›PMID 37858193›Full record

ArticleBMC research notes2023

Molecular detection of Epstein-Barr virus among Sudanese patients diagnosed with Hashimoto's thyroiditis.

Marowa N Hamad, Fuodat I Mohamed, Mayada M Osman, Ahlam A Jadid, Ibtihal K Abdalrhman, Alaa M Yousif, Tyseer Alabid, Ali Mahmoud Mohammed Edris, Nouh S Mohamed, Emmanuel Edwar Siddig and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  5. The firstClinical case reports · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Marowa N HamadDepartment of Hematology and immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Fuodat I MohamedDepartment of Hematology and immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Mayada M OsmanDepartment of Hematology and immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Ahlam A JadidDepartment of Hematology and immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Ibtihal K AbdalrhmanDepartment of Hematology and immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Alaa M YousifMolecular Biology Unit, Sirius Training and Research Centre, Khartoum, Sudan.
Tyseer AlabidDepartment of Hematology and immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Ali Mahmoud Mohammed EdrisDepartment of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Nouh S MohamedMolecular Biology Unit, Sirius Training and Research Centre, Khartoum, Sudan. nouh_saad@outlook.com.
Emmanuel Edwar SiddigFaculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, 11111, Sudan.
Ayman AhmedInstitute of Endemic Diseases, University of Khartoum, Khartoum, 11111, Sudan. ayman.ahmed@uofk.edu.ORCID http://orcid.org/0000-0002-9516-9508
University of Khartoum · SDNational Centre for Research · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHashimoto's thyroiditis (HT) is the most common cause of hypothyroidism. The exact mechanism initiating the development of HT is not yet clear. This study aimed to investigate the correlation between HT and the presence of Epstein-Barr virus (EBV) in a Sudanese population.

resultsEBV-LMP1 was detected in 11.1% of HT cases, which is consistent with previous studies. Studies have reported a wide range of frequencies indicating the presence of EBV in HT, and patients with autoimmune thyroiditis have increased titers of anti-EBV antibodies in their sera compared to healthy subjects. Intrathyroidal EBV-infected B cells may be responsible for the increased risk of development of B-cell lymphoma in the thyroid gland in patients with autoimmune thyroiditis. Our study suggests that regular follow-up is necessary for patients diagnosed with HT and are positive for EBV, as antiviral therapy is not applicable due to the risk of thyroid dysfunction. The study suggests an association between EBV and HT, but causation cannot be determined. The study also highlights the need for further research to determine the viral role and correlate it with the severity and progression of HT.

Indexed as

Epstein-Barr Virus InfectionsHashimoto DiseaseThyroiditis, AutoimmuneHerpesvirus 4, HumanHumansEpstein-Barr virusHashimoto ThyroiditisMolecular detectionSudan

Identifiers

PMID37858193
PMCPMC10588233
OpenAlexW4387782528

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.