Evidence map›Paper›PMID 37858122›Full record

ArticleBMC pediatrics2023

Impact of a publicly-funded pharmacare program policy on benzodiazepine dispensing among children and youth: a population-based natural experiment.

Tony Antoniou, Daniel McCormack, Sophie Kitchen, Kathleen Pajer, William Gardner, Yona Lunsky, Melanie Penner, Mina Tadrous, Muhammad Mamdani, David N Juurlink and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Tony AntoniouLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. Tony.antoniou@unityhealth.to.
Daniel McCormackICES, Toronto, ON, Canada.
Sophie KitchenICES, Toronto, ON, Canada.
Kathleen PajerChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
William GardnerICES, Toronto, ON, Canada.
Yona LunskyICES, Toronto, ON, Canada.
Melanie PennerAutism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada.
Mina TadrousICES, Toronto, ON, Canada.
Muhammad MamdaniLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
David N JuurlinkICES, Toronto, ON, Canada.
Tara GomesLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Institute for Clinical Evaluative Sciences · CAUniversity of Toronto · CASt. Michael's Hospital · CAChildren's Hospital of Eastern Ontario · CAHealth Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn January 2018, the Government of Ontario, Canada, initiated a universal pharmacare program (OHIP+) for all individuals aged 24 years and younger. In April 2019, the program was amended to cover only children and youth without private insurance. Because benzodiazepines are commonly prescribed to children and youth despite their potential hazards, we examined whether changes in publicly-funded drug coverage influenced benzodiazepine dispensing trends in this demographic.

methodsWe conducted a population-based natural experiment study of benzodiazepine dispensing to children and youth in Ontario between January 2013 and March 2020. We used interventional autoregressive integrated moving average models to estimate the impact of OHIP + and its subsequent modification on these trends.

resultsThe implementation of OHIP + was associated with an immediate increase in the monthly rate of benzodiazepine dispensing of 12.9 individuals per 100,000 population (95% confidence interval [CI]; 7.5 to 18.3 per 100,000). Benzodiazepine dispensing rates rose from 214.2 to 241.5 per 100,000 from December 2017 to March 2019, a 12.8% (95% CI 9.6-16.0%) increase. In stratified analyses, increases were most pronounced among females, children and youth living in the lowest income neighbourhoods and individuals aged 20 to 24. The April 2019 modification to OHIP + was not associated with changes in monthly benzodiazepine dispensing trends (0.39 individuals per 100,000; 95% CI -1.3 to 2.1 per 100,000). However, rates remained elevated relative to the period preceding OHIP + implementation.

conclusionsImplementation of a publicly-funded pharmacare program resulted in more children and youth being prescribed benzodiazepines.

Indexed as

BenzodiazepinesPolicyAdolescentChildFemaleHumansOntarioBenzodiazepinesAdolescentBenzodiazepinesChildPolicyPrescriptions / statistics & numerical data

Identifiers

PMID37858122
PMCPMC10585894
OpenAlexW4387766119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.