SynthesisBMC oral health2023
Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Examining the Role of Vitamin D in Caries Susceptibility in Children's Deciduous Teeth: A Systematic Review.Nutrients · 2023Pooled it
- Nutrient intake and oral health outcomes in children with cow's milk allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Serum 25(OH)D Levels and Dental Caries Experience in Children: A Cross-Sectional Study.Oral health & preventive dentistry · 2026Article
- Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.Journal of clinical medicine · 2026Article
- Association between vitamin D supplementation and the prevalence of dental caries and gingivitis in children. A cross-sectional study.Clinical oral investigations · 2025Article
- Caries status influence GCF MMP-9 in association with serum vitamin D: an exploratory retrospective cross-sectional study.BMC oral health · 2025Article
- Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D.Journal of family medicine and primary care · 2025Article
- Article
- Investigation of root apical closure of first permanent molars with cone-beam computed tomography: A retrospective study.Journal of dental sciences · 2024Article
- The Association of Vitamin D Levels and Dental Caries in Older Adults: A Cross-Sectional Study.Nutrients · 2024Article
- Associations of Serum Vitamin D With Dental Caries and Periodontitis: The HUNT Study.International dental journal · 2024Article
- The Influence of Vitamin D Levels on Dental Caries: A Retrospective Study of the United States Population.Nutrients · 2024Article
- Article
- A Systematic Review of the Relationship between Serum Vitamin D Levels and Caries in the Permanent Teeth of Children and Adolescents.Dentistry journal · 2024Review
- The association between serum vitamin D status and dental caries or molar incisor hypomineralisation in 7-9-year-old Norwegian children: a cross-sectional study.BMC public health · 2024Article
- Strategies to build stronger bones in Indian children: Challenges for implementation.The Indian journal of medical researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D plays a crucial role in oral health, and its deficiency is associated to significant changes in oral health diseases. We aimed to explore the relationship between levels of 25-hydroxyvitamin D (25(OH) D) and dental caries in children.
methodsFour electronic databases were searched by two investigators including PubMed, Embase, Web of Science, and Cochrane Library. Dental caries results were presented as either prevalence or based on the index of primary and permanent teeth/surfaces with decaying, missing, and filled areas, while vitamin D levels were determined through laboratory testing. Two researchers independently selected studies, collected information, assessed risk of bias, and evaluated the study quality. Any disagreements were resolved through discussion.
resultsA total of 13 studies were included, comprising 5 cross-sectional studies, 5 cohort studies, 3 case-control studies, all of which had high methodological quality. Our meta-analysis showed that children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels, with a relative risk (RR) of 1.22 and a 95% confidence interval (CI) of 1.18 to 1. 25. Further subgroup analysis according to the three types of studies showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (cohort studies: 62%; cross-sectional studies, 19%; and case-control studies, 5%). Additionally, according to age, subgroup analysis also showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (permanent teeth studies, 28%; deciduous teeth studies, 68%; and mixed dentition studies 8%).
conclusionsLevels of 25 (OH) D have been found negatively associated with dental caries in children, indicating that low vitamin D levels may be considered a potential risk factor to this dental disease.
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Registered trials
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