Evidence map›Paper›PMID 37858065›Full record

Observational studyBMC neurology2023

Association between neutrophil-to-albumin ratio and long-term mortality of aneurysmal subarachnoid hemorrhage.

Renjie Zhang, Yu Zhang, Zheran Liu, Yiyan Pei, Yan He, Jiayi Yu, Chao You, Lu Ma, Fang Fang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. The role of neutrophils in vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: Is it time for a SAH clinical trial targeting neutrophils?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renjie Zhang *Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yu Zhang *Center for Evidence Based Medical and Clinical Research, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Zheran LiuDepartment of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yiyan PeiDepartment of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yan HeDepartment of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Jiayi YuSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Chao YouDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Lu MaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China. alex80350305@scu.edu.cn.
Fang FangDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China. fangfang01@scu.edu.cn.

Funding

Clinical Incubation Program of West China Hospital, SCU 2018HXFU008the 1·3·5 projects for disciplines of excellence-Clinical Research Incubation Project 21HXFH046the National Key R&D Program of China 2018YFA0108604the project of the health commission of Sichuan province 19PJ003the project of the Sichuan Science and Technology Bureau 2020YFS0490the Science and Technology Department Project of Sichuan Province 2021YJ0015
6 · The paper itself

Abstract

objectiveThe prognosis of aneurysmal subarachnoid hemorrhage (aSAH) survivors is concerning. The goal of this study was to investigate and demonstrate the relationship between the neutrophil-to-albumin ratio (NAR) and long-term mortality of aSAH survivors.

methodsA retrospective observational cohort study was conducted at Sichuan University West China Hospital between January 2009 and June 2019. The investigation of relationship between NAR and long-term mortality was conducted using univariable and multivariable Cox regression models. To demonstrate the predictive performance of different biomarkers over time, time-dependent receiver operating characteristic curve (ROC) analysis and decision curve analysis (DCA) were created.

resultsIn total, 3173 aSAH patients were included in this study. There was a strong and continuous relationship between NAR levels and long-term mortality (HR 3.23 95% CI 2.75-3.79, p < 0.001). After adjustment, the result was still significant (adjusted HR 1.78 95% CI 1.49-2.12). Compared with patients with the lowest quartile (< 0.15) of NAR levels, the risk of long-term mortality in the other groups was higher (0.15-0.20: adjusted HR 1.30 95% CI 0.97-1.73; 0.20-0.28: adjusted HR 1.37 95% CI 1.03-1.82; >0.28: adjusted HR 1.74 95% CI 1.30-2.32). Results in survivors were found to be still robust. Moreover, out of all the inflammatory markers studied, NAR demonstrated the highest correlation with long-term mortality.

conclusionsA high level of NAR was associated with increased long-term mortality among patients with aSAH. NAR was a promising inflammatory marker for long-term mortality of aSAH.

Indexed as

NeutrophilsSubarachnoid HemorrhageAlbuminsBiomarkersHumansLeukocyte CountPrognosisRetrospective StudiesAlbuminsBiomarkersIntracranial AneurysmMortalityNeutrophil-to-albuminPrognosisSubarachnoid Hemorrhage

Identifiers

PMID37858065
PMCPMC10585913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.