ArticleThe international journal of cardiovascular imaging2024
Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation.
Article in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 17 citations in OpenAlex.
- Relationship between epicardial adipose tissue and left atrial stiffness estimated from echocardiographic parameters and left atrial pressure in patients with atrial fibrillation.Heart and vessels · 2026Article
- Left atrial stiffness as a predictor of one-year mortality after transcatheter aortic valve replacement.Journal of echocardiography · 2026Article
- Nonlinear association and threshold effect between preoperative estimated pulse wave velocity and postoperative atrial fibrillation after coronary artery bypass grafting.Journal of thoracic disease · 2026Article
- Pre-procedural left atrial strain and clinical features for predicting recurrence after first catheter ablation of persistent atrial fibrillation: a prospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Beyond body mass index: visceral adiposity and metabolic alterations as early markers of atrial dysfunction and atrial fibrillation in midlife.Frontiers in endocrinology · 2026Observational
- Diagnostic value of left atrial three-dimensional strain for paroxysmal atrial fibrillation in patients with acute ischemic stroke.Frontiers in cardiovascular medicine · 2026Article
- Left atrial stiffness as a novel echocardiographic parameter of atrial dysfunction in cats with hypertrophic cardiomyopathy: A two-dimensional speckle-tracking study.Veterinary world · 2025Article
- Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.PLoS computational biology · 2025Article
- Deep phenotyping of left atrial characteristics: sphericity and stiffness stratify patients with atrial fibrillation and cardioembolic stroke.The international journal of cardiovascular imaging · 2025Article
- Is regional atrial strain a useful surrogate of regional atrial fibrosis in atrial cardiomyopathy?European heart journal. Imaging methods and practice · 2025Article
- Article
- Left atrial reservoir strain as a predictor of cardiac dysfunction in a murine model of pressure overload.Acta physiologica (Oxford, England) · 2025Article
- Prognostic value of left atrial stiffness in patients undergoing transcatheter aortic valve implantation.International journal of cardiology. Heart & vasculature · 2025Article
- Exploring the causes of stiff left atrial syndrome: a case series.European heart journal. Case reports · 2025Article
- Cancer, Inflammation, and Thrombosis: Drivers of Atrial Fibrillation in Oncology Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
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11 authors at 2 institutions in 2 countries.
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Abstract
A relationship between left atrial strain and pressure has been demonstrated in many studies, but not in an atrial fibrillation (AF) cohort. In this work, we hypothesized that elevated left atrial (LA) tissue fibrosis might mediate and confound the LA strain vs. pressure relationship, resulting instead in a relationship between LA fibrosis and stiffness index (mean LA pressure/LA reservoir strain). Sixty-seven patients with AF underwent a standard cardiac MR exam including long-axis cine views (2 and 4-ch) and a free-breathing high resolution three-dimensional late gadolinium enhancement (LGE) of the atrium (N = 41), within 30 days prior to AF ablation, at which procedure invasive mean left atrial pressure (LAP) was measured. LV and LA Volumes, EF, and comprehensive analysis of LA strains (strain and strain rates and strain timings during the atrial reservoir, conduit and active, i.e. active atrial contraction, phases) were measured and LA fibrosis content (LGE (ml)) was assessed from 3D LGE volumes. LA LGE was well correlated to atrial stiffness index overall (R = 0.59, p < 0.001), and among patient subgroups. Pressure was only correlated to maximal LA volume (R = 0.32) and the time to peak reservoir strain rate (R = 0.32) (both p < 0.01), among all functional measurements. LA reservoir strain was strongly correlated with LAEF (R = 0.95, p < 0.001) and LA minimum volume (r = 0.82, p < 0.001). In our AF cohort, pressure is correlated to maximum LA volume and time to peak reservoir strain. LA pressure/ LA reservoir strain, a metric of stiffness, correlates with LA fibrosis (LA LGE), reflecting Hook's Law.
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