Evidence map›Paper›PMID 37857906›Full record

ArticleNature methods2023

Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion.

Xinyue Liu, Siyuan Rao, Weixuan Chen, Kayla Felix, Jiahua Ni, Atharva Sahasrabudhe, Shaoting Lin, Qianbin Wang, Yuanyuan Liu, Zhigang He and 6 more

Open access · greenAbstract read
In one paragraph

Article in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 85 citations in OpenAlex.

  1. Design, Construction, and Application of Implantable Fiber Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026
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  9. Curvy Surface Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  19. Review
  20. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Xinyue Liu *Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. xyliu@msu.edu.ORCID 0000-0002-1187-493X
Siyuan Rao *Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, USA. syrao@binghamton.edu.ORCID 0000-0002-1555-487X
Weixuan ChenDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0009-0003-2374-6681
Kayla FelixDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, USA.
Jiahua NiDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Atharva SahasrabudheResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Shaoting LinDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Qianbin WangDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, USA.
Yuanyuan LiuSomatosensation and Pain Unit, National Institute of Dental and Craniofacial Research, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.
Zhigang HeF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6080-6880
Jingyi XuDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, USA.
Sizhe HuangDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0009-0003-8923-8946
Eunji HongDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, USA.
Todd YauDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.
Polina Anikeeva *Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu.ORCID 0000-0001-6495-5197
Xuanhe Zhao *Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. zhaox@mit.edu.ORCID 0000-0001-5387-6186
Binghamton University · USMassachusetts Institute of Technology · USUniversity of Massachusetts Amherst · USMcGovern Institute for Brain Research · USBoston Children's Hospital · USNational Institutes of Health · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood VesselsR01HL153857 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHAO, XUANHE · 2020 to 2024
$2.4M
Optogenetics to improve hand function after spinal cord injury.R01NS115025 · NINDS · UNIVERSITY OF WASHINGTON · PI ANIKEEVA, POLINA O, MORITZ, CHET T. · 2020 to 2023
$2.4M
Fiber Inspired Neural Probes for the Multifunctional Dynamic Brain MappingR01NS086804 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2015 to 2019
$1.7M
Magnetic Modulation on Targeted Neural Circuits in AutismR00MH120279 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI RAO, SIYUAN · 2021 to 2023
$747k
Magnetic Modulation on Targeted Neural Circuits in AutismK99MH120279 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RAO, SIYUAN · 2019 to 2020
$164k
NHLBI NIH HHS R01 HL153857NICHD NIH HHS P50 HD105351NIMH NIH HHS K99 MH120279NIMH NIH HHS R00 MH120279NINDS NIH HHS R01 NS086804NINDS NIH HHS R01 NS115025
6 · The paper itself

Abstract

We develop soft and stretchable fatigue-resistant hydrogel optical fibers that enable optogenetic modulation of peripheral nerves in naturally behaving animals during persistent locomotion. The formation of polymeric nanocrystalline domains within the hydrogels yields fibers with low optical losses of 1.07 dB cm

Indexed as

Optical FibersOptogeneticsAnimalsHydrogelsLocomotionMiceMotor ActivitySciatic NerveHydrogels

Identifiers

PMID37857906
PMCPMC11009937
OpenAlexW4387773556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.