ArticleNature human behaviour2024
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.
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Article in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23citing papers in PubMed, 1 pooled it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
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- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- Human genetics across levels of biological organization.Nature reviews. Genetics · 2026Review
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- Forecasting Alzheimer's disease progression via identity-preserved denoising diffusion generative adversarial network.NPJ digital medicine · 2026Article
- A longitudinal analysis of T1-weighted MRI features associated with progression from mild cognitive impairment to Alzheimer's disease.BMC medical imaging · 2026Article
- Shared genetic architecture between the topology of brain white matter structural connectome and fluid intelligence.Communications biology · 2026Article
- Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.Journal of advanced research · 2026Article
- Genome-wide analysis implicates inner ear development in Ménière's disease.medRxiv : the preprint server for health sciences · 2026Article
- Comparison of Three Automated Measurements of Ventricular Volumes of the Brain.Journal of imaging informatics in medicine · 2026Article
- Quo Vadis translational neuroscience?Translational neuroscience · 2026Review
- Silk-enabled conformal intraventricular interfaces for minimally invasive neural recordings.Nature communications · 2025Article
- Molecular hallmarks of hydrocephalus.Science translational medicine · 2025Review
- Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Atlas of Proteomic signatures of brain structure and its links to brain disorders.Nature communications · 2025Article
- Genome-wide interaction association analysis identifies interactive effects of childhood maltreatment and kynurenine pathway on depression.Nature communications · 2025Article
- Genome-wide association study unravels mechanisms of brain glymphatic activity.Nature communications · 2025Article
- The effect of pituitary neuroendocrine tumors on the volumes of intracranial structures.Frontiers in neurology · 2025Article
- NADCell death & disease · 2024Article
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Authors and funding
44 authors at 18 institutions in 7 countries.
Yi-Jun Ge *Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Bang-Sheng Wu *Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Yi Zhang *Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Shi-Dong ChenDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Ya-Ru ZhangDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Ju-Jiao KangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-4489-7281
Yue-Ting DengDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Ya-Nan OuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Xiao-Yu HeDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Yong-Li ZhaoDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Kevin KuoDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Qing MaInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4595-1144
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5214-7421
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-0114-4914
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4809-5398
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Penny GowlandSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-4900-4817
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0001-5405-9065
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.ORCID http://orcid.org/0000-0003-0111-5996
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-0136-0388
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0003-4461-7646
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-7796-8234
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-1242-8990
Herve LemaitreNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-5952-076X
Tomáš PausDepartments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-1495-9338
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5175-6698
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-8493-6396
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine, Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-4600-7158
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
IMAGEN Consortium
Jian-Feng FengInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Qiang DongDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-3874-0130
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine, Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-7740-6469
Wei ChengDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. wcheng@fudan.edu.cn.ORCID http://orcid.org/0000-0003-1118-1743
Jin-Tai YuDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. jintai_yu@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2532-383X
Fudan University · CNCentre National de la Recherche Scientifique · FRHeidelberg University · DEQingdao University · CNCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHumboldt-Universität zu Berlin · DEKing's College London · GBTechnische Universität Dresden · DETrinity College Dublin · IECharité - Universitätsmedizin Berlin · DEHuashan Hospital · CNPhysikalisch-Technische Bundesanstalt · DEShanghai Medical College of Fudan University · CNUniversity of Mannheim · DEUniversity of Nottingham · GBUniversity of Toronto · CAUniversity of Vermont · USZhejiang Normal University · CN
Funding
Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1Medical Research Council MR/W002418/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759
Abstract
The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits. Genome-wide association analysis in a discovery sample of 31,880 individuals identified 62 unique loci and 785 candidate genes associated with ventricular morphology. We replicated over 80% of loci in a well-matched cohort of lateral ventricular volume. Gene set analysis revealed enrichment of ventricular-trait-associated genes in biological processes and disease pathogenesis during both early brain development and degeneration. We explored the age-dependent genetic associations in cohorts of different age groups to investigate the possible roles of ventricular-trait-associated loci in neurodevelopmental and neurodegenerative processes. We describe the genetic overlap between ventricular and neuropsychiatric traits through comprehensive integrative approaches under correlative and causal assumptions. We propose the volume of the inferior lateral ventricles as a heritable endophenotype to predict the risk of Alzheimer's disease, which might be a consequence of prodromal Alzheimer's disease. Our study provides an advance in understanding the genetics of the cerebral ventricles and demonstrates the potential utility of ventricular measurements in tracking brain disorders and maintaining brain health across the lifespan.
Indexed as
Alzheimer DiseaseAdolescentAdultAgedAged, 80 and overBrainCerebral VentriclesChildGenome-Wide Association StudyHumansMiddle AgedPhenotypeYoung Adult
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