ArticlePediatric research2024
Maturation of cardioventilatory physiological trajectories in extremely preterm infants.
Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 21 citations in OpenAlex.
- Time spent within the SpOBMJ open respiratory research · 2026Trial
- Prediction of bronchopulmonary dysplasia seven days after birth using respiratory and oxygenation timeseries with machine learning.Pediatric research · 2026Article
- Maturational physiology in preterm infants: morbidity impact and 2-year neurodevelopmental outcome.Pediatric research · 2026Article
- Car seat tolerance screen failure in the neonatal intensive care unit: clinical, oxygen saturation and heart rate analysis.Pediatric research · 2026Article
- Home Oxygen Use and Post-Discharge Management of Infants with Bronchopulmonary Dysplasia.Clinics in perinatology · 2026Review
- Not all apneas are created equal: parsing the ones that matter in preterm infants.Pediatric research · 2026Article
- Intermittent hypoxemia metrics enhance bronchopulmonary dysplasia severity predictions in extremely low gestational age newborns.Pediatric research · 2026Article
- Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Definitions and monitoring methods for apnea in preterm infants: a scoping review.Pediatric research · 2026Article
- Cardiorespiratory phase synchronization maturational trajectory: biomarker of autonomic nervous system development in preterm infants.Pediatric research · 2026Article
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- Physiological Stability During Kangaroo Mother Care Among Very-Low-Birthweight Premature Infants, Supported by Non-Invasive Respiratory Support.Journal of paediatrics and child health · 2025Observational
- Future perspectives of heart rate and oxygenation monitoring in the neonatal intensive care unit - a narrative review.Journal of clinical monitoring and computing · 2025Review
- Oxygenation Instability and Short-Term Morbidities Among Very-Low-Birthweight Premature Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Caffeine for Persistent Intermittent Hypoxia in Newborns With and Without Chronic Lung Disease.Pediatric pulmonology · 2025Article
- Neonatal intermittent hypoxemia events are associated with later systemic hypertension.Pediatric research · 2025Article
- Interprofessional perspectives on non-invasive respiratory support practices in extremely preterm infants: a Canadian survey.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Effect of Intermittent Hypoxemia and Hyperoxemia during the Neonatal Period on Control of Breathing Function among Infants Born Extremely Preterm.The Journal of pediatrics · 2025Observational
- Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
21 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundIn extremely preterm infants, persistence of cardioventilatory events is associated with long-term morbidity. Therefore, the objective was to characterize physiologic growth curves of apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants during the first few months of life.
methodsThe Prematurity-Related Ventilatory Control study included 717 preterm infants <29 weeks gestation. Waveforms were downloaded from bedside monitors with a novel sharing analytics strategy utilized to run software locally, with summary data sent to the Data Coordinating Center for compilation.
resultsApnea, periodic breathing, and intermittent hypoxemia events rose from day 3 of life then fell to near-resolution by 8-12 weeks of age. Apnea/intermittent hypoxemia were inversely correlated with gestational age, peaking at 3-4 weeks of age. Periodic breathing was positively correlated with gestational age peaking at 31-33 weeks postmenstrual age. Females had more periodic breathing but less intermittent hypoxemia/bradycardia. White infants had more apnea/periodic breathing/intermittent hypoxemia. Infants never receiving mechanical ventilation followed similar postnatal trajectories but with less apnea and intermittent hypoxemia, and more periodic breathing.
conclusionsCardioventilatory events peak during the first month of life but the actual postnatal trajectory is dependent on the type of event, race, sex and use of mechanical ventilation. IMPACT: Physiologic curves of cardiorespiratory events in extremely preterm-born infants offer (1) objective measures to assess individual patient courses and (2) guides for research into control of ventilation, biomarkers and outcomes. Presented are updated maturational trajectories of apnea, periodic breathing, intermittent hypoxemia, and bradycardia in 717 infants born <29 weeks gestation from the multi-site NHLBI-funded Pre-Vent study. Cardioventilatory events peak during the first month of life but the actual postnatal trajectory is dependent on the type of event, race, sex and use of mechanical ventilation. Different time courses for apnea and periodic breathing suggest different maturational mechanisms.
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