ArticleNature cell biology2023
A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing.
Article in Nature cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Progress toward linking single-molecule behavior and condensate material properties.Current opinion in structural biology · 2026Review
- Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a model of Alzheimer's disease.Disease models & mechanisms · 2026Article
- Advancing mechanobiology from single molecules to complex cellular systems.Nature nanotechnology · 2026Review
- Engineering Design of Artificial Phase-Separating Proteins.Biotechnology journal · 2026Review
- Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule.Science advances · 2026Article
- Single-particle tracking reveals heterogeneous PIEZO1 diffusion.Biophysical journal · 2025Article
- In situ structure of a gap junction-stomatin complex.Science advances · 2025Article
- Obstacles Regulate Membrane Tension Propagation to Enable Localized Mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- Structural basis for membrane microdomain formation by a human Stomatin complex.Nature communications · 2025Article
- Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology.Nature nanotechnology · 2025Article
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.eLife · 2025Article
- Automated dual olfactory device for studying head/tail chemosensation inAPL bioengineering · 2024Article
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Authors and funding
11 authors.
Funding
Abstract
A growing body of work suggests that the material properties of biomolecular condensates ensuing from liquid-liquid phase separation change with time. How this aging process is controlled and whether the condensates with distinct material properties can have different biological functions is currently unknown. Using Caenorhabditis elegans as a model, we show that MEC-2/stomatin undergoes a rigidity phase transition from fluid-like to solid-like condensates that facilitate transport and mechanotransduction, respectively. This switch is triggered by the interaction between the SH3 domain of UNC-89 (titin/obscurin) and MEC-2. We suggest that this rigidity phase transition has a physiological role in frequency-dependent force transmission in mechanosensitive neurons during body wall touch. Our data demonstrate a function for the liquid and solid phases of MEC-2/stomatin condensates in facilitating transport or mechanotransduction, and a previously unidentified role for titin homologues in neurons.
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