Evidence map›Paper›PMID 37857824›Full record

ArticleNature nanotechnology2024

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower.

Mathias Centola, Erik Poppleton, Sujay Ray, Martin Centola, Robb Welty, Julián Valero, Nils G Walter, Petr Šulc, Michael Famulok

Abstract read
In one paragraph

Article in Nature nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Programming DNA machines to move.Nature reviews. Chemistry · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Wireframe DNA Origami Capable of Vertex-protruding Transformation.Chembiochem : a European journal of chemical biology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mathias CentolaLIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.ORCID 0000-0001-9310-3866
Erik PoppletonSchool of Molecular Sciences and Center for Molecular Design and Biomimetics, The Biodesign Institute, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-5146-5970
Sujay RaySingle Molecule Analysis Group, Department of Chemistry, Ann Arbor, MI, USA.ORCID 0000-0003-1076-0436
Martin CentolaMax-Planck-Institute of Biophysics, Frankfurt, Germany.ORCID 0000-0003-0956-5705
Robb WeltySingle Molecule Analysis Group, Department of Chemistry, Ann Arbor, MI, USA.ORCID 0000-0002-8362-5297
Julián ValeroLIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany.ORCID 0000-0002-5260-2770
Nils G WalterSingle Molecule Analysis Group, Department of Chemistry, Ann Arbor, MI, USA. nwalter@umich.edu.ORCID 0000-0002-7301-1275
Petr ŠulcLIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany. psulc@asu.edu.ORCID 0000-0003-1565-6769
Michael FamulokLIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, Universität Bonn, Bonn, Germany. m.famulok@uni-bonn.de.ORCID 0000-0001-5878-6577

Funding

The RNA nanomachines of the gene expression machinery dissected at the single molecule levelR35GM131922 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NILS G WALTER · 2019 to 2026
$6.9M
National Science Foundation TG-BIO210009NIGMS NIH HHS R35 GM131922
6 · The paper itself

Abstract

Molecular engineering seeks to create functional entities for modular use in the bottom-up design of nanoassemblies that can perform complex tasks. Such systems require fuel-consuming nanomotors that can actively drive downstream passive followers. Most artificial molecular motors are driven by Brownian motion, in which, with few exceptions, the generated forces are non-directed and insufficient for efficient transfer to passive second-level components. Consequently, efficient chemical-fuel-driven nanoscale driver-follower systems have not yet been realized. Here we present a DNA nanomachine (70 nm × 70 nm × 12 nm) driven by the chemical energy of DNA-templated RNA-transcription-consuming nucleoside triphosphates as fuel to generate a rhythmic pulsating motion of two rigid DNA-origami arms. Furthermore, we demonstrate actuation control and the simple coupling of the active nanomachine with a passive follower, to which it then transmits its motion, forming a true driver-follower pair.

Indexed as

NanostructuresDNAMotionRNATranscription, GeneticDNARNA

Identifiers

PMID37857824
PMCPMC10873200

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.