Evidence map›Paper›PMID 37857414›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Correlation of the methylomic signature of smoking during pregnancy with clinical traits in ADHD.

Boris Chaumette, Natalie Grizenko, Weam Fageera, Marie-Ève Fortier, Marina Ter-Stepanian, Aurelie Labbe, Ridha Joober

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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Boris ChaumetteFrom the Douglas Mental Health University Institute, Montréal, Que. (Chaumette, Grizenko, Fageerat, Fortier, Ter-Stepanian, Joober); the Department of Psychiatry, McGill University, Montréal, Que. (Chaumette, Grizenko, Joober); The Neuro, McGill University, Montréal, Que. (Chaumette); the Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France (Chaumette); the GHU Paris Psychiatrie & Neurosciences, Paris, France (Chaumette); the Department of Human Genetics, McGill University, Montréal, Que. (Fageera, Joober); the Department of Educational and Counselling Psychology, McGill University, Montréal, Que. (Ter-Stepanian); the Département de Psychoéducation, Université de Sherbrooke, Que. (Ter-Stepanian); the Department of Decision Sciences, HEC Montreal, Montréal, Que. (Labbe); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Joober).
Natalie GrizenkoFrom the Douglas Mental Health University Institute, Montréal, Que. (Chaumette, Grizenko, Fageerat, Fortier, Ter-Stepanian, Joober); the Department of Psychiatry, McGill University, Montréal, Que. (Chaumette, Grizenko, Joober); The Neuro, McGill University, Montréal, Que. (Chaumette); the Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France (Chaumette); the GHU Paris Psychiatrie & Neurosciences, Paris, France (Chaumette); the Department of Human Genetics, McGill University, Montréal, Que. (Fageera, Joober); the Department of Educational and Counselling Psychology, McGill University, Montréal, Que. (Ter-Stepanian); the Département de Psychoéducation, Université de Sherbrooke, Que. (Ter-Stepanian); the Department of Decision Sciences, HEC Montreal, Montréal, Que. (Labbe); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Joober).
Weam FageeraFrom the Douglas Mental Health University Institute, Montréal, Que. (Chaumette, Grizenko, Fageerat, Fortier, Ter-Stepanian, Joober); the Department of Psychiatry, McGill University, Montréal, Que. (Chaumette, Grizenko, Joober); The Neuro, McGill University, Montréal, Que. (Chaumette); the Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France (Chaumette); the GHU Paris Psychiatrie & Neurosciences, Paris, France (Chaumette); the Department of Human Genetics, McGill University, Montréal, Que. (Fageera, Joober); the Department of Educational and Counselling Psychology, McGill University, Montréal, Que. (Ter-Stepanian); the Département de Psychoéducation, Université de Sherbrooke, Que. (Ter-Stepanian); the Department of Decision Sciences, HEC Montreal, Montréal, Que. (Labbe); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Joober).
Marie-Ève FortierFrom the Douglas Mental Health University Institute, Montréal, Que. (Chaumette, Grizenko, Fageerat, Fortier, Ter-Stepanian, Joober); the Department of Psychiatry, McGill University, Montréal, Que. (Chaumette, Grizenko, Joober); The Neuro, McGill University, Montréal, Que. (Chaumette); the Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France (Chaumette); the GHU Paris Psychiatrie & Neurosciences, Paris, France (Chaumette); the Department of Human Genetics, McGill University, Montréal, Que. (Fageera, Joober); the Department of Educational and Counselling Psychology, McGill University, Montréal, Que. (Ter-Stepanian); the Département de Psychoéducation, Université de Sherbrooke, Que. (Ter-Stepanian); the Department of Decision Sciences, HEC Montreal, Montréal, Que. (Labbe); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Joober).
Marina Ter-StepanianFrom the Douglas Mental Health University Institute, Montréal, Que. (Chaumette, Grizenko, Fageerat, Fortier, Ter-Stepanian, Joober); the Department of Psychiatry, McGill University, Montréal, Que. (Chaumette, Grizenko, Joober); The Neuro, McGill University, Montréal, Que. (Chaumette); the Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France (Chaumette); the GHU Paris Psychiatrie & Neurosciences, Paris, France (Chaumette); the Department of Human Genetics, McGill University, Montréal, Que. (Fageera, Joober); the Department of Educational and Counselling Psychology, McGill University, Montréal, Que. (Ter-Stepanian); the Département de Psychoéducation, Université de Sherbrooke, Que. (Ter-Stepanian); the Department of Decision Sciences, HEC Montreal, Montréal, Que. (Labbe); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Joober).
Aurelie LabbeFrom the Douglas Mental Health University Institute, Montréal, Que. (Chaumette, Grizenko, Fageerat, Fortier, Ter-Stepanian, Joober); the Department of Psychiatry, McGill University, Montréal, Que. (Chaumette, Grizenko, Joober); The Neuro, McGill University, Montréal, Que. (Chaumette); the Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France (Chaumette); the GHU Paris Psychiatrie & Neurosciences, Paris, France (Chaumette); the Department of Human Genetics, McGill University, Montréal, Que. (Fageera, Joober); the Department of Educational and Counselling Psychology, McGill University, Montréal, Que. (Ter-Stepanian); the Département de Psychoéducation, Université de Sherbrooke, Que. (Ter-Stepanian); the Department of Decision Sciences, HEC Montreal, Montréal, Que. (Labbe); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Joober).
Ridha JooberFrom the Douglas Mental Health University Institute, Montréal, Que. (Chaumette, Grizenko, Fageerat, Fortier, Ter-Stepanian, Joober); the Department of Psychiatry, McGill University, Montréal, Que. (Chaumette, Grizenko, Joober); The Neuro, McGill University, Montréal, Que. (Chaumette); the Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France (Chaumette); the GHU Paris Psychiatrie & Neurosciences, Paris, France (Chaumette); the Department of Human Genetics, McGill University, Montréal, Que. (Fageera, Joober); the Department of Educational and Counselling Psychology, McGill University, Montréal, Que. (Ter-Stepanian); the Département de Psychoéducation, Université de Sherbrooke, Que. (Ter-Stepanian); the Department of Decision Sciences, HEC Montreal, Montréal, Que. (Labbe); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Joober) ridha.joober@douglas.mcgill.ca.
HEC Montréal · CAInstitut de Psychiatrie et Neurosciences de Paris · FRMcGill University · CAMontreal Neurological Institute and Hospital · CAUniversité de Sherbrooke · CAUniversité Paris Cité · FR

Funding

CIHR MOP 126023CIHR MOP 53309CIHR MOP 84537
6 · The paper itself

Abstract

backgroundAttention deficit/hyperactivity disorder (ADHD) is a highly prevalent childhood disorder. Maternal smoking during pregnancy is a replicated environmental risk factor for this disorder. It is also a robust modifier of gene methylation during the prenatal developmental period. In this study, we sought to identify loci differentially methylated by maternal smoking during pregnancy and relate their methylation levels to various behavioural and physical outcomes relevant to ADHD.

methodsWe extracted DNA from blood samples from children diagnosed with ADHD and deeply phenotyped. Genome-wide DNA methylation was assessed using Infinium MethylationEPIC BeadChip. Maternal smoking during pregnancy was self-declared and assessed retrospectively.

resultsOur sample included 231 children with ADHD. Statistically significant differences in DNA methylation between children exposed or not to maternal smoking during pregnancy were detected in 3457 CpGs. We kept 30 CpGs with at least 5% of methylation difference between the 2 groups for further analysis. Six genes were associated with varied phenotypes of clinical relevance to ADHD. The levels of DNA methylation in LIMITATIONS: The study has several limitations, including the retrospective recall with self-report of maternal smoking during pregnancy as well as the grouping of individuals of varying age and developmental stage and of both males and females. In addition, the correlation design prevents the building of causation models.

conclusionThis study provides evidence for the association between the level of methylation at specific loci and quantitative dimensions highly relevant for ADHD as well as birth weight, a measure that has already been associated with increased risk for ADHD. Our results provide further support to public health educational initiatives to stop maternal smoking during pregnancy.

Indexed as

Attention Deficit Disorder with HyperactivityPrenatal Exposure Delayed EffectsBirth WeightChildCore Binding Factor Alpha 2 SubunitDNA MethylationFemaleHumansMalePhenotypePregnancyRetrospective StudiesSmokingCore Binding Factor Alpha 2 Subunit

Identifiers

PMID37857414
PMCPMC10599658
OpenAlexW4387774304

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.