ArticlePloS one2023
Importance of mobile genetic elements for dissemination of antimicrobial resistance in metagenomic sewage samples across the world.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Long-read metagenomics and methylation-based binning support the discovery of antibiotic resistance gene-host associations in complex communities.Genome biology · 2026Article
- Reducing Antibiotic Dependence in Poultry: The Potential of Phytochemicals as Antibiotic Alternatives Against Bacterial Foodborne Pathogens.Tropical medicine and infectious disease · 2026Review
- The plasmid-host fitness landscape: a new paradigm for predicting the fate of mobile resistance.Applied and environmental microbiology · 2026Review
- Mobilome-driven antimicrobial resistance in a one health context: evidence and lessons from Africa.Frontiers in veterinary science · 2026Review
- Article
- Distribution and molecular characterization of integron classes fromMicrobiology spectrum · 2025Article
- Environmental drivers of the resistome across the Baltic Sea.Microbiome · 2025Article
- The Impact of Wastewater on Antimicrobial Resistance: A Scoping Review of Transmission Pathways and Contributing Factors.Antibiotics (Basel, Switzerland) · 2025Review
- Investigation of mobile genetic elements and their association with antibiotic resistance genes in clinical pathogens worldwide.PloS one · 2025Article
- Mobile genetic elements and wastewater treatment: contaminants of emerging concern, climate change, and trophic transmission.Frontiers in microbiology · 2025Review
- Metagenomic surveillance of microbial community and antibiotic resistant genes associated with Malaysian wastewater during the COVID-19 pandemic.Current genetics · 2024Article
- Characterization and comparative analysis of antimicrobial resistance inJournal of water and health · 2024Article
- Antimicrobial Resistance Elements in Coastal Water of Llanquihue Lake, Chile.Antibiotics (Basel, Switzerland) · 2024Article
- Antimicrobial Resistance and Virulence Potential of Bacterial Species from Captive Birds of Prey-Consequences of Falconry for Public Health.Animals : an open access journal from MDPI · 2024Review
- Unseen Weapons: Bacterial Extracellular Vesicles and the Spread of Antibiotic Resistance in Aquatic Environments.International journal of molecular sciences · 2024Review
- ARGprofiler-a pipeline for large-scale analysis of antimicrobial resistance genes and their flanking regions in metagenomic datasets.Bioinformatics (Oxford, England) · 2024Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are facing an ever-growing threat from increasing antimicrobial resistance (AMR) in bacteria. To mitigate this, we need a better understanding of the global spread of antimicrobial resistance genes (ARGs). ARGs are often spread among bacteria by horizontal gene transfer facilitated by mobile genetic elements (MGE). Here we use a dataset consisting of 677 metagenomic sequenced sewage samples from 97 countries or regions to study how MGEs are geographically distributed and how they disseminate ARGs worldwide. The ARGs, MGEs, and bacterial abundance were calculated by reference-based read mapping. We found systematic differences in the abundance of MGEs and ARGs, where some elements were prevalent on all continents while others had higher abundance in separate geographic areas. Different MGEs tended to be localized to temperate or tropical climate zones, while different ARGs tended to separate according to continents. This suggests that the climate is an important factor influencing the local flora of MGEs. MGEs were also found to be more geographically confined than ARGs. We identified several integrated MGEs whose abundance correlated with the abundance of ARGs and bacterial genera, indicating the ability to mobilize and disseminate these genes. Some MGEs seemed to be more able to mobilize ARGs and spread to more bacterial species. The host ranges of MGEs seemed to differ between elements, where most were associated with bacteria of the same family. We believe that our method could be used to investigate the population dynamics of MGEs in complex bacterial populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.