Evidence map›Paper›PMID 37856468›Full record

ArticlePloS one2023

Placental characteristics and neonatal weights among women with malaria-preeclampsia comorbidity and healthy pregnancies.

Everett Lwamulungi, Zahida Qureshi, Moses Obimbo, Omondi Ogutu, Eunice Cheserem, Rose J Kosgei, Edwin Walong, Dennis Inyangala, George G Nyakundi, Patrick M Ndavi and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Everett LwamulungiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.ORCID 0009-0005-8315-4295
Zahida QureshiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Moses ObimboDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Omondi OgutuDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Eunice CheseremDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Rose J KosgeiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Edwin WalongKenyatta National Hospital, Nairobi, Kenya.
Dennis InyangalaKenyatta National Hospital, Nairobi, Kenya.
George G NyakundiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.ORCID 0000-0001-7245-8959
Patrick M NdaviDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Alfred O OsotiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Diana K OndiekiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Anne N PuleiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Anne NjorogeKenyatta National Hospital, Nairobi, Kenya.
Sarah MasyukoKenyatta National Hospital, Nairobi, Kenya.
Cyrus M WachiraKenyatta National Hospital, Nairobi, Kenya.
University of Nairobi · KEUniversity of Washington · USKenyatta National Hospital · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria and preeclampsia are leading causes of maternal morbidity and mortality in sub-Saharan Africa. They contribute significantly to poor perinatal outcomes like low neonatal weight by causing considerable placental morphological changes that impair placental function. Previous studies have described the effects of either condition on the placental structure but the structure of the placenta in malaria-preeclampsia comorbidity is largely understudied despite its high burden. This study aimed to compare the placental characteristics and neonatal weights among women with malaria-preeclampsia comorbidity versus those with healthy pregnancies. METHODOLOGY: We conducted a retrospective cohort study among 24 women with malaria-preeclampsia comorbidity and 24 women with healthy pregnancies at a County Hospital in Western Kenya. Neonatal weights, gross and histo-morphometric placental characteristics were compared among the two groups.

resultsThere was a significant reduction in neonatal weights (P<0.001), placental weights (P = 0.028), cord length (P<0.001), and cord diameter (P<0.001) among women with malaria-preeclampsia comorbidity compared to those with healthy pregnancies. There was also a significant reduction in villous maturity (P = 0.016) and villous volume density (P = 0.012) with increased villous vascularity (P<0.007) among women with malaria-preeclampsia comorbidity compared to those with healthy pregnancies.

conclusionPlacental villous maturity and villous volume density are significantly reduced in patients with malaria-preeclampsia comorbidity with a compensatory increase in villous vascularity. This leads to impaired placental function that contributes to lower neonatal weights.

Indexed as

MalariaPre-EclampsiaComorbidityFemaleHumansInfant, NewbornPlacentaPregnancyRetrospective Studies

Identifiers

PMID37856468
PMCPMC10586625
OpenAlexW4387772027

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.