Evidence map›Paper›PMID 37856427›Full record

ArticleACS infectious diseases2024

Synthetic Glycans Reveal Determinants of Antibody Functional Efficacy against a Fungal Pathogen.

Conor J Crawford, Lorenzo Guazzelli, Scott A McConnell, Orla McCabe, Clotilde d'Errico, Seth D Greengo, Maggie P Wear, Anne E Jedlicka, Arturo Casadevall, Stefan Oscarson

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Automated Synthesis of Algal Fucoidan Oligosaccharides.Journal of the American Chemical Society · 2024
    Article
  5. Article
  6. Article
  7. A consensus structural motif for the capsular polysaccharide ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. The structure of aProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Semi-synthetic glycoconjugate vaccine candidate againstbioRxiv : the preprint server for biology · 2024
    Article
  10. The structure of abioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Conor J CrawfordCentre for Synthesis and Chemical Biology, University College Dublin, Belfield D04 V1W8, Dublin 4, Ireland.ORCID 0000-0002-1314-1019
Lorenzo GuazzelliCentre for Synthesis and Chemical Biology, University College Dublin, Belfield D04 V1W8, Dublin 4, Ireland.ORCID 0000-0003-4655-2946
Scott A McConnellDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, United States.
Orla McCabeCentre for Synthesis and Chemical Biology, University College Dublin, Belfield D04 V1W8, Dublin 4, Ireland.
Clotilde d'ErricoCentre for Synthesis and Chemical Biology, University College Dublin, Belfield D04 V1W8, Dublin 4, Ireland.
Seth D GreengoDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, United States.
Maggie P WearDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, United States.
Anne E JedlickaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, United States.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, United States.
Stefan OscarsonCentre for Synthesis and Chemical Biology, University College Dublin, Belfield D04 V1W8, Dublin 4, Ireland.ORCID 0000-0002-8273-4918
Johns Hopkins University · USUniversity College Dublin · IE

Funding

Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
Exploiting antibody catalysis for treating CryptococcosisR01AI162381 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2021 to 2025
$3.7M
NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI152078NIAID NIH HHS R01 AI162381
6 · The paper itself

Abstract

Antibodies play a vital role in the immune response to infectious diseases and can be administered passively to protect patients. In the case of

Indexed as

CryptococcosisCryptococcus neoformansAntibodies, FungalAntibodies, MonoclonalEpitopesHumansPolysaccharidesAntibodies, FungalAntibodies, MonoclonalEpitopesPolysaccharidesantibodiesCryptococcus neoformansepitopesglycansimmunologyvaccines

Identifiers

PMID37856427
PMCPMC10862557
OpenAlexW4387770910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.