Evidence map›Paper›PMID 37856072›Full record

ReviewCurrent urology reports2023

Pathophysiologic Insights into the Transition from Asymptomatic Bacteriuria to Urinary Tract Infection.

Bernardita M Ljubetic, Ashu Mohammad, Butool Durrani, Amy D Dobberfuhl

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current urology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Bernardita M LjubeticDepartment of Urology, Center for Academic Medicine, Urology-5656, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA.ORCID http://orcid.org/0000-0001-7367-5939
Ashu MohammadDepartment of Urology, Center for Academic Medicine, Urology-5656, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA.ORCID http://orcid.org/0000-0001-6494-720X
Butool DurraniDepartment of Internal Medicine, Aga Khan University Hospital, National Stadium Rd, Karachi, Karachi City, Pakistan.ORCID http://orcid.org/0009-0003-4401-3903
Amy D DobberfuhlDepartment of Urology, Center for Academic Medicine, Urology-5656, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA. adobber@stanford.edu.ORCID http://orcid.org/0000-0003-3451-3878
Stanford University · USAga Khan University Hospital · PKStanford Medicine · US

Funding

Signal integration by specialized mesenchyme in urothelial homeostasis and Interstitial Cystitis / Bladder Pain SyndromeR01DK134989 · NIDDK · STANFORD UNIVERSITY · PI BEACHY, PHILIP A · 2022 to 2025
$3.0M
Validation of a Neurogenic Bladder Management Solution to Promote Independence and Reduce Long-Term Morbidity for Patients Unable to Perform Intermittent CatheterizationR44DK127580 · NIDDK · CRM MEDICAL DEVICES, INC. · PI ELLIOTT, CHRISTOPHER, EVERSULL, CHRISTIAN S · 2022 to 2023
$1.5M
NIH HHS NIH 1R01CA249807NIH HHS NIH 1R01DK134989NIH HHS NIH 2R44DK127580
6 · The paper itself

Abstract

purpose of reviewAsymptomatic bacteriuria (ASB) can be found in the general population but it is more common in catheterized patients. Some patients develop urinary tract infections (UTI) and others stay asymptomatic throughout time. The scientific community lacks a pathophysiologic explanation of why asymptomatic bacteriuria stays asymptomatic most of the time, and why and how it sometimes transitions to UTI. In an attempt to bridge this gap in knowledge, a summary of the current literature is conducted on the pathophysiologic differences between ASB and UTI, beyond their clinical differences. RECENT

findingsASB and UTI cannot be differentiated just by their phylogroup or number of virulence factors. The difference may be in their metabolism gene expression. The literature lacks a pathophysiological explanation of the transition from ASB to UTI, and recent discoveries suggest that metabolic gene expression may hold the key.

Indexed as

BacteriuriaCatheter-Related InfectionsUrinary Tract InfectionsAnti-Bacterial AgentsHumansAnti-Bacterial AgentsAdultBacteriuriaCatheter-related infections/diagnosisEscherichia coliHumansUrinary tract infections/diagnosis

Identifiers

PMID37856072
OpenAlexW4387764711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.