Evidence map›Paper›PMID 37856068›Full record

ArticleJournal of nephrology2023

Histological and clinical evaluation of discarded kidneys in a European cohort of deceased brain death donor kidneys of marginal quality.

Florian G Scurt, Carl-Ludwig Fischer-Fröhlich, Tamara Wassermann, Angela Ernst, Anke Schwarz, Jan U Becker, Christos Chatzikyrkou

Abstract read
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In one paragraph

Article in Journal of nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The early impacts of an attempt to standardize kidney procurement biopsy practices.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Florian G ScurtUniversity Clinic for Nephrology and Hypertension, Diabetology and Endocrinology, Otto-von Guericke University, Magdeburg, Germany.ORCID 0000-0001-6197-4720
Carl-Ludwig Fischer-FröhlichDeutsche Stiftung Organtransplantation (Region Baden-Württemberg), Stuttgart, Germany.ORCID 0000-0003-0867-7668
Tamara WassermannOtto-von Guericke University, Magdeburg, Germany.ORCID 0000-0001-8822-6992
Angela ErnstInstitute of Medical Statistics and Bioinformatics, University of Cologne, Cologne, Germany.ORCID 0000-0003-2375-1889
Anke SchwarzDepartment of Nephrology and Hypertension, Hannover Medical School, Carl-Neuberg Str. 1, 30655, Hannover, Germany.
Jan U BeckerInstitute of Pathology, University Hospital of Cologne, Cologne, Germany.ORCID 0000-0003-2929-8085
Christos ChatzikyrkouDepartment of Nephrology and Hypertension, Hannover Medical School, Carl-Neuberg Str. 1, 30655, Hannover, Germany. chatziky@gmx.de.ORCID 0000-0002-6723-2346
Medizinische Hochschule Hannover · DEUniversity of Cologne · DEGerman Organ Transplantation Foundation · DEUniversity Clinic for Nephrology and Hypertension, Diabetology and Endocrinology · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite organ shortages, the discard rate of deceased donor kidneys is high. Risk factors for this trend warrant further study.

methodsWe investigated reasons for discard in a cohort of brain death donors with marginal kidneys and procurement biopsies. Paraffin embedded procurement biopsies were systematically reevaluated and graded for the purpose of the study. Assessment included percentage of global glomerulosclerosis, Banff Lesion scores and tubular epithelial damage. Donor-, transplant process-, perfusion quality-, histopathology-, and recipient-related parameters were compared between discarded and transplanted organs.

resultsAlthough most clinical characteristics were similar between donors whose kidneys were transplanted and those whose kidneys were procured but discarded, discarded kidneys were more likely to be from donors with hepatitis C, to have undergone wedge biopsies, to show changes of acute and chronic injury and to be deemed poor quality. Except for obvious anatomic abnormalities, kidneys were often discarded due to the findings of procurement biopsies. Donors of kidneys discarded for histologic reasons more often had hypertension, coronary artery disease, stroke, and increased serum creatinine. The reason for discard was unknown in 20% of cases. Discarded kidneys came from donors who appeared to be clinically similar to donors whose kidneys were utilized for transplant.

conclusionA considerable proportion of discarded kidneys were of acceptable quality. The analysis of the outcome of every recovered organ could help to overcome this problem. Procurement biopsies more often lead to discard than to transplantation of recovered organs. Proper handling during allocation has to be determined.

Indexed as

Kidney TransplantationBrain DeathDonor SelectionGraft SurvivalHumansKidneyTissue DonorsDeceased brain death donorsKidney allocationMarginal kidneysProcurement biopsiesTransplantation

Identifiers

PMID37856068
OpenAlexW4387765676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.