Evidence map›Paper›PMID 37855360›Full record

ArticleCurrent diabetes reviews2024

The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy.

Ebrahim Ebrat, Seyyedeh Mina Hejazian, Elham Ahmadian, Sepideh Zununi Vahed, Majid Mobasseri, Mohammadreza Ardalan

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Article in Current diabetes reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ebrahim EbratKidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Seyyedeh Mina HejazianKidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Elham AhmadianKidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Sepideh Zununi VahedKidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Majid MobasseriEndocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammadreza ArdalanKidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

Kidney Research Center at Tabriz University of Medical Sciences, Tabriz, Iran 60770, 62798
6 · The paper itself

Abstract

backgroundDiabetic nephropathy (DN) is a common complication of type 2 diabetes (T2D). Chronic inflammation and a combination of environmental and genetic factors are involved in the pathogenesis and development of DN.

objectiveThis case-control study aimed to determine the relationship between rs7529229 and rs2228145 polymorphisms of the IL-6R gene with the incidence of nephropathy among T2D patients.

methodsFifty-six diabetic patients with nephropathy and 57 T2D patients without nephropathy were included based on inclusion criteria, along with 150 healthy individuals.

resultsThe frequencies of AC and CC genotype distributions of the rs2228145 polymorphism in DN patients were significantly higher than in healthy individuals (24.1 and 9.3% versus 10.7 and 6.7%, respectively, P= 0.02). Moreover, the frequency of allele C was higher in DN patients compared to healthy controls (21.30%

conclusionThe results showed that the allele and genotype distribution frequencies of rs2228145 IL-6R gene polymorphism in patients with DN were significantly higher than in healthy individuals. Therefore, the presence of this polymorphism may be involved in the development of diabetic nephropathy in this population.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesGene FrequencyGenetic Predisposition to DiseasePolymorphism, Single NucleotideReceptors, Interleukin-6AdultAgedCase-Control StudiesFemaleGenotypeHumansMaleMiddle AgedIL6R protein, humanReceptors, Interleukin-6chronic inflammation.cytokinediabetic nephropathy (DN)Gene polymorphismIL-6R geneType 2 diabetes (T2D)

Identifiers

PMID37855360

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