Evidence map›Paper›PMID 37855354›Full record

ArticleCombinatorial chemistry & high throughput screening2024

Network Pharmacology and Molecular Docking Analysis on Mechanisms of Scutellariae Radix in the Treatment of Cerebral Ischemia-reperfusion Injury.

Yang Yang, Mengrong Xu, Wenting Yuan, Yue Feng, Yongqiang Hou, Fei Fang, Shiwan Duan, Lu Bai

Abstract read
PubMed Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang YangDepartment of Pharmacy, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, China.ORCID 0000-0002-7930-970X
Mengrong XuDepartment of Pharmacy, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, China.ORCID 0009-0004-0428-8571
Wenting YuanDepartment of College of Life Sciences, Northwest University, No. 229, North Taibai Road, Beilin District, China.ORCID 0009-0009-7091-4311
Yue FengDepartment of College of Life Sciences, Northwest University, No. 229, North Taibai Road, Beilin District, China.ORCID 0000-0002-1976-6458
Yongqiang HouDepartment of Pharmacy, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, China.ORCID 0009-0007-9595-1691
Fei FangDeparment of Central Lab, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, China.
Shiwan DuanDepartment of Pharmacy, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, China.
Lu BaiDepartment of Pharmacy, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, China.ORCID 0000-0002-5942-4401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple brain disorders are treated by Scutellaria Radix (SR), including cerebral ischemia-reperfusion (CI/R). However, more studies are needed to clarify the molecular mechanism of SR for CI/R.

methodsThe active substances and potential targets of SR and CI/R-related genes were obtained through public databases. Overlapping targets of SR and CI/R were analyzed using proteinprotein interaction (PPI) networks. GO and KEGG enrichment analyses were performed to predict the pathways of SR against CI/R, and the key components and targets were screened for molecular docking. The results of network pharmacology analysis were verified using in vitro experiments.

results15 components and 64 overlapping targets related to SR and CI/R were obtained. The top targets were AKT1, IL-6, CAS3, TNF, and TP53. These targets have been studied by GO and KEGG to be connected to a number of signaling pathways, including MAPK, PI3K-Akt pathway, and apoptosis. Molecular docking and cell experiments helped to further substantiate the network pharmacology results.

conclusionThe active compound of SR was able to significantly decrease the apoptosis of HT- 22 cells induced by OGD/R. This finding suggests that SR is a potentially effective treatment for CI/R by modulating the MAPK and PI3K-Akt pathways.

Indexed as

Molecular Docking SimulationNetwork PharmacologyReperfusion InjuryScutellaria baicalensisApoptosisBrain IschemiaDrugs, Chinese HerbalHumansProtein Interaction MapsDrugs, Chinese Herbalapoptosisbaicalincerebral ischemia/reperfusionMAPK signaling pathwaymolecular dockingNetwork pharmacologyPI3K/AKT signaling pathway.Scutellariae Radix

Identifiers

PMID37855354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.