ReviewEndocrine connections2023
Relationship between serum uric acid levels and osteoporosis.
Review in Endocrine connections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Recent advances in research on the association between paediatric hyperuricaemia and bone health.Frontiers in endocrinology · 2026Pooled it
- Deciphering the interplay between serum urate and bone mineral density: insights from observational and genetic perspectives.Journal of the International Society of Sports Nutrition · 2026Article
- Allopurinol has no effect on calcitriol or other CKD-MBD biomarkers: a randomized double-blind study.Journal of the Endocrine Society · 2026Article
- An intelligent auxiliary diagnostic system for early osteoporosis screening using stacking ensemble learning.BMC medical informatics and decision making · 2026Article
- Association between serum uric acid levels and osteoporosis risk: evidence from a cross-sectional study and Mendelian randomization analysis.Clinical rheumatology · 2026Article
- Construction of a nomogram prediction model for individualized prediction of vertebral compression fracture risk in postmenopausal osteoporosis population.Scientific reports · 2026Article
- Development and validation of a robust logistic regression model for predicting osteoporosis in older people.Frontiers in medicine · 2026Article
- Association between platelet-to-albumin ratio and total spine bone mineral density in older adults with thoracolumbar fragility fractures: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Association between the Dietary Index for Gut Microbiota and osteoporosis: a cross-sectional study from NHANES among individuals aged ≥ 50 years.Archives of medical science : AMS · 2026Article
- Influence of serum uric acid on bone mineral density across body mass index categories in men with type 2 diabetes: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments.European journal of medical research · 2025Article
- The ratio of serum uric acid to high-density lipoprotein cholesterol as a predictor for frailty prevalence and mortality in the elderly U.S. adults.Lipids in health and disease · 2025Article
- Value of serum uric acid in a risk prediction model for postmenopausal osteoporosis.Archives of gynecology and obstetrics · 2025Article
- Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging.Journal of orthopaedic surgery and research · 2025Article
- Association between serum uric acid levels and bone mineral density in Chinese and American: a cross-sectional study.Scientific reports · 2025Article
- Relationship Among Fragility Fractures and the Overall Cardiovascular Burden in Endogenous Cushing Syndrome.Journal of the Endocrine Society · 2025Article
- Development and validation of an explainable machine learning model for predicting osteoporosis in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Nonlinear Association Between Serum Uric Acid and Femoral Neck Bone Mineral Density in Male Patients with Metabolic Dysfunction-Associated Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Correlation analysis between serum uric acid and carotid intima-media thickness: a cross sectional study.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis (OP) is a systemic bone disease in which bone density and quality decrease and bone fragility increases due to a variety of causes, making it prone to fractures. The development of OP is closely related to oxidative stress. Uric acid (UA) is the end product of purine metabolism in the human body. Extracellular UA has antioxidant properties and is thought to have a protective effect on bone metabolism. However, the process of UA degradation can lead to intracellular oxidative stress, which together with UA-induced inflammatory factors, leads to increased bone destruction. In addition, UA can inhibit vitamin D production, resulting in secondary hyperparathyroidism and further exacerbating UA-associated bone loss. This review summarizes the relationship between serum UA levels and bone mineral density, bone turnover markers, and so on, in the hope of providing new insights into the pathogenesis and treatment of OP.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.