Evidence map›Paper›PMID 37854935›Full record

ArticleProceedings of machine learning research2023

Optimizing Dynamic Antibiotic Treatment Strategies against Invasive Methicillin-Resistant

Inyoung Jun, Scott A Cohen, Sarah E Ser, Simone Marini, Robert J Lucero, Jiang Bian, Mattia Prosperi

Open access · greenAbstract read
In one paragraph

Article in Proceedings of machine learning research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Inyoung JunDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Scott A CohenDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Sarah E SerDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Simone MariniDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Robert J LuceroSchool of Nursing, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jiang BianDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Mattia ProsperiDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
University of Florida · USUniversity of California, Los Angeles · US

Funding

Developing Computational Methods for Surveillance of Antimicrobial Resistant AgentsR01AI141810 · NIAID · UNIVERSITY OF FLORIDA · PI BOUCHER, CHRISTINA, PROSPERI, MATTIA · 2019 to 2023
$2.1M
Advancing Interdisciplinary Science of Aging through Identification of Iatrogenic Complications: The UF EHR Clinical Data Infrastructure for Enhanced Patient Safety among the Elderly (UF-ECLIPSE)R33AG062884 · NIA · UNIVERSITY OF FLORIDA · PI INGIBJARGARDOTTIR BJARNADOTTIR, RAGNHILDUR, LUCERO, ROBERT J · 2021 to 2023
$2.1M
NIAID NIH HHS R01 AI141810NIA NIH HHS R33 AG062884
6 · The paper itself

Abstract

Developing models for individualized, time-varying treatment optimization from observational data with large variable spaces, e.g., electronic health records (EHR), is problematic because of inherent, complex bias that can change over time. Traditional methods such as the g-formula are robust, but must identify critical subsets of variables due to combinatorial issues. Machine learning approaches such as causal survival forests have fewer constraints and can provide fine-tuned, individualized counterfactual predictions. In this study, we aimed to optimize time-varying antibiotic treatment -identifying treatment heterogeneity and conditional treatment effects- against invasive methicillin-resistant

Indexed as

Antibiotic ResistanceCausal Machine LearningCausal Survival ForestDynamic Treatment OptimizationG-FormulaIndividualized Treatment Effect

Identifiers

PMID37854935
PMCPMC10584043
OpenAlexW4387765234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.