Evidence map›Paper›PMID 37854885›Full record

ReviewFrontiers in bioengineering and biotechnology2023

Porous biomaterial scaffolds for skeletal muscle tissue engineering.

Natalie G Kozan, Mrunmayi Joshi, Sydnee T Sicherer, Jonathan M Grasman

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  8. Edible Scaffolds for Cultivated Meat Production.Advances in biochemical engineering/biotechnology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Skeletal Muscle Tissue Engineering: From Tissue Regeneration to Biorobotics.Cyborg and bionic systems (Washington, D.C.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natalie G KozanDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States.
Mrunmayi JoshiDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States.
Sydnee T SichererDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States.
Jonathan M GrasmanDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States.
New Jersey Institute of Technology · US

Funding

Institutional Career Development CoreKL2TR003018 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI CHAN, JOHN R., HALM, ETHAN A · 2019 to 2023
$3.0M
Acellular composite hydrogel scaffolds for volumetric muscle regenerationR21AR079708 · NIAMS · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI GRASMAN, JONATHAN M., KUMAR, VIVEK · 2022 to 2023
$467k
NCATS NIH HHS KL2 TR003018NIAMS NIH HHS R21 AR079708
6 · The paper itself

Abstract

Volumetric muscle loss is a traumatic injury which overwhelms the innate repair mechanisms of skeletal muscle and results in significant loss of muscle functionality. Tissue engineering seeks to regenerate these injuries through implantation of biomaterial scaffolds to encourage endogenous tissue formation and to restore mechanical function. Many types of scaffolds are currently being researched for this purpose. Scaffolds are typically made from either natural, synthetic, or conductive polymers, or any combination therein. A major criterion for the use of scaffolds for skeletal muscle is their porosity, which is essential for myoblast infiltration and myofiber ingrowth. In this review, we summarize the various methods of fabricating porous biomaterial scaffolds for skeletal muscle regeneration, as well as the various types of materials used to make these scaffolds. We provide guidelines for the fabrication of scaffolds based on functional requirements of skeletal muscle tissue, and discuss the general state of the field for skeletal muscle tissue engineering.

Indexed as

biomaterialporosityscaffoldskeletal muscleskeletal muscle tissue engineeringtissue engineeringvolumetric muscle loss

Identifiers

PMID37854885
PMCPMC10579822
OpenAlexW4387306727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.