Evidence map›Paper›PMID 37854697›Full record

ArticleiScience2023

Biomarkers of alcohol abuse potentially predict delirium, delirium duration and mortality in critically ill patients.

Nikolaus Schreiber, Alexander C Reisinger, Stefan Hatzl, Nikolaus Schneider, Laura Scholz, Markus Herrmann, Michael Kolland, Max Schuller, Alexander H Kirsch, Kathrin Eller and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Nikolaus SchreiberDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Alexander C ReisingerDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Stefan HatzlDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Nikolaus SchneiderDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Laura ScholzDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Markus HerrmannClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Michael KollandDepartment of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
Max SchullerDepartment of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
Alexander H KirschDepartment of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
Kathrin EllerDepartment of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
Christiane KinkDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Simon Fandler-HöflerDepartment of Neurology, Medical University Graz, Graz, Austria.
Alexander R RosenkranzDepartment of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria.
Gerald HacklDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Philipp EllerDepartment of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
Medical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbohydrate-deficient transferrin (CDT) and the γ-glutamyltransferase-CDT derived Anttila-Index are established biomarkers for sustained heavy alcohol consumption and their potential role to predict delirium and mortality in critically ill patients is not clear. In our prospective observational study, we included 343 consecutive patients admitted to our ICU, assessed the occurrence of delirium and investigated its association with biomarkers of alcohol abuse measured on the day of ICU admission. 35% of patients developed delirium during ICU stay. We found significantly higher CDT levels (p = 0.011) and Anttila-Index (p = 0.001) in patients with delirium. CDT above 1.7% (OR 2.06), CDT per percent increase (OR 1.26, AUROC 0.75), and Anttila-Index per unit increase (OR 1.28, AUROC 0.74) were associated with delirium development in adjusted regression models. Anttila-Index and CDT also correlated with delirium duration exceeding 5 days. Additionally, Anttila-Index above 4, Anttila-Index per unit increase, and CDT per percent increase were independently associated with hospital mortality.

Indexed as

clinical findingmedical science

Identifiers

PMID37854697
PMCPMC10579439
OpenAlexW4387045362

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.