Evidence map›Paper›PMID 37854619›Full record

ArticleACS pharmacology & translational science2023

Early-Stage Development of an Anti-Evaporative Liposomal Formulation for the Potential Treatment of Dry Eyes.

Janika Jäntti, Tuomo Viitaja, Julia Sevón, Tatu Lajunen, Jan-Erik Raitanen, Cordula Schlegel, Mira Viljanen, Riku O Paananen, Jukka Moilanen, Marika Ruponen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Translating Biomarker Discovery: From Bench to Bedside in Dry Eye Disease.International journal of molecular sciences · 2025
    Review
  3. Decipher 'Em All: A Profiling Study on the Effects of Acyl Groups inLangmuir : the ACS journal of surfaces and colloids · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Janika JänttiSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Tuomo ViitajaDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.
Julia SevónDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.ORCID https://orcid.org/0000-0002-2609-0863
Tatu LajunenSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Jan-Erik RaitanenDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.ORCID https://orcid.org/0000-0002-2818-7570
Cordula SchlegelDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.
Mira ViljanenDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.
Riku O PaananenDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.ORCID https://orcid.org/0000-0002-2703-6359
Jukka MoilanenOphthalmology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, FI-00290 Helsinki, Finland.
Marika RuponenSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Filip S EkholmDepartment of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland.ORCID https://orcid.org/0000-0002-4461-2215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry eye disease (DED), the most common ocular disorder, reduces the quality of life for hundreds of millions of people annually. In healthy eyes, the tear film lipid layer (TFLL) stabilizes the tear film and moderates the evaporation rate of tear fluid. In >80% of DED cases, these central features are compromised leading to tear film instability and excessive evaporation of tear fluid. Herein we assess the potential of liposomal formulations featuring phosphatidylcholines and tailored lipid species from the wax ester and

Identifiers

PMID37854619
PMCPMC10580384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.